Tsukamoto I, Kojo S
Department of Food Science and Nutrition, Nara Womens' University, Japan.
Eur J Pharmacol. 1987 Dec 1;144(2):159-62. doi: 10.1016/0014-2999(87)90515-2.
The activity of hepatic thymidylate synthetase and thymidine kinase at 24 h after 70% partial hepatectomy of rats was suppressed significantly compared with that in the control group by the administration of calcium channel blockers (verapamil, diltiazem and nifedipine) 8 h after partial hepatectomy. The decrease of thymidylate synthetase and thymidine kinase activities was accompanied by a reduction of DNA content in 24 h regenerating liver. Trifluoperazine showed an effect similar to that of the calcium channel blockers on DNA synthesis during liver regeneration. These results suggest that calcium entry into the hepatic cell is an essential event in liver regeneration.
大鼠70%肝部分切除术后8小时给予钙通道阻滞剂（维拉帕米、地尔硫䓬和硝苯地平），与对照组相比，术后24小时肝胸苷酸合成酶和胸苷激酶的活性显著受到抑制。胸苷酸合成酶和胸苷激酶活性的降低伴随着24小时再生肝中DNA含量的减少。三氟拉嗪在肝脏再生过程中对DNA合成的作用与钙通道阻滞剂相似。这些结果表明，钙离子进入肝细胞是肝脏再生中的一个重要事件。
