糖皮质激素对大鼠部分肝切除术后肝脏再生的影响。
Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat.
作者信息
Tsukamoto I, Kojo S
机构信息
Department of Food Science and Nutrition, Nara Women's University, Japan.
出版信息
Gut. 1989 Mar;30(3):387-90. doi: 10.1136/gut.30.3.387.
Abstract
The increase in activities of hepatic thymidylate synthetase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21), which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocortisone and dexamethasone) or indomethacin. These drugs also prevented the augment of hepatic DNA content in 24 h regenerating liver.
摘要
在给予糖皮质激素（氢化可的松和地塞米松）或吲哚美辛的大鼠肝脏再生过程中，催化分别通过从头合成途径和补救途径形成胸苷酸的肝胸苷酸合成酶（EC 2.1.1.45）和胸苷激酶（EC 2.7.1.21）的活性增加受到显著抑制。这些药物还阻止了24小时再生肝脏中肝DNA含量的增加。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
EFFECT OF ADRENOCORTICOTROPHIC HORMONE AND CORTISONE ON THE UPTAKE OF TRITIATED THYMIDINE BY REGENERATING LIVER TISSUE IN THE WHITE RAT.促肾上腺皮质激素和可的松对白鼠再生肝组织摄取氚标记胸腺嘧啶的影响
Nature. 1964 Feb 29;201:930-1. doi: 10.1038/201930a0.
3
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
4
Effects of cortisone on regenerating rat liver.可的松对大鼠再生肝脏的影响。
J Gen Physiol. 1954 Mar;37(4):559-74. doi: 10.1085/jgp.37.4.559.
5
An early mitosis-determining event in regenerating rat liver and its possible mediation by prostaglandins or thromboxane.
J Cell Physiol. 1982 Nov;113(2):281-8. doi: 10.1002/jcp.1041130216.
6
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Nature. 1984;310(5979):697-8. doi: 10.1038/310697a0.
7
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Cancer Res. 1969 Feb;29(2):366-72.
8
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Experientia. 1969 Dec 15;25(12):1240-2. doi: 10.1007/BF01897470.
9
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10
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Hepatology. 1985 Jan-Feb;5(1):43-6. doi: 10.1002/hep.1840050110.
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