Carvalho Suzana Gonçalves, Dos Santos Aline Martins, Silvestre Amanda Letícia Polli, Meneguin Andréia Bagliotti, Ferreira Leonardo Miziara Barboza, Chorilli Marlus, Gremião Maria Palmira Daflon
Department of Drugs and Pharmaceutics, School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil.
Department of Drugs and Pharmaceutics, School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil.
Carbohydr Polym. 2021 Nov 1;271:118436. doi: 10.1016/j.carbpol.2021.118436. Epub 2021 Jul 14.
Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. Although many studies address the formation of polyelectrolyte complexes (PECs), few explore strategies and tools to select the best working conditions and are often based on empirical choices. This study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of PECs based on chitosan:dextran sulfate. In addition, it assesses the approaches that study the influence of pH on the zeta potential of polymeric dispersions as a tool in the design of PECs. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH proved to be a promising tool in the choice of polymers and a better pH condition in the development of PECs.
聚电解质络合是一种基于超分子相互作用驱动的相反电荷聚电解质之间相互作用的技术。尽管许多研究涉及聚电解质复合物（PEC）的形成，但很少有研究探索选择最佳工作条件的策略和工具，且往往基于经验选择。本研究评估了pH值、分子量和聚合物比例对基于壳聚糖：硫酸葡聚糖的PEC形成的影响。此外，它还评估了将研究pH值对聚合物分散体zeta电位的影响作为PEC设计工具的方法。结果表明，聚阳离子过量的纳米颗粒形成聚集体，而硫酸葡聚糖过量则会减小颗粒尺寸。zeta电位随pH值变化的曲线被证明是选择聚合物和开发PEC时更好的pH条件的一个有前景的工具。
