London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom.
Vaccine. 2021 Aug 31;39(37):5277-5284. doi: 10.1016/j.vaccine.2021.06.074. Epub 2021 Aug 6.
Human papillomavirus (HPV) infections are mostly sexually transmitted and cause the greatest share of infection-associated cancers. Each year more than half a million women are diagnosed with cervical cancer and the mortality rate in West Africa is over ten times higher than that of Northern Europe. HPV vaccines are highly effective at preventing various strains of the infection. However, vaccine hesitancy and access issues have led to low HPV vaccine acceptance in certain countries. A search strategy was developed in PubMed and included an extensive list of keywords and related MeSH/subject headings to capture the many dimensions and expressions of vaccine access, confidence, trust and hesitancy related to HPV vaccination in West Africa. Thirty-five articles were included by full text. Most studies were conducted in Nigeria. Three were conducted in Mali, and one each in Côte d'Ivoire, Ghana and Senegal. The main concerns relating to the vaccine were inadequate information, cost and safety concerns. Several studies also mentioned fertility and promiscuity concerns. Despite over half of West African countries introducing an HPV vaccine pilot project, there is a scarcity of literature on HPV vaccine acceptance in the region. It is important to understand how cultural and gender dynamics in different settings can influence peoples' vaccination decisions. This can be done through in-depth local ethnographies, taking the views of all community members and influencers into account, and complemented by in-depth individual interviews and focus groups.
人乳头瘤病毒（HPV）感染主要通过性传播，是导致感染相关癌症的最大原因。每年有超过 50 万名女性被诊断出患有宫颈癌，而西非的死亡率比北欧高出 10 多倍。HPV 疫苗在预防各种感染株方面非常有效。然而，疫苗犹豫和可及性问题导致某些国家 HPV 疫苗的接种率较低。我们在 PubMed 中制定了搜索策略，其中包含了广泛的关键词和相关的 MeSH/主题词列表，以捕捉与 HPV 疫苗接种相关的疫苗可及性、信心、信任和犹豫的许多方面和表达。共纳入 35 篇文章。大多数研究在尼日利亚进行，3 项在马里进行，1 项在科特迪瓦、加纳和塞内加尔进行。与疫苗相关的主要问题是信息不足、费用和安全问题。一些研究还提到了对生育和滥交的担忧。尽管超过一半的西非国家都开展了 HPV 疫苗试点项目，但该地区关于 HPV 疫苗接种的文献却很少。了解不同环境中的文化和性别动态如何影响人们的接种决定非常重要。这可以通过深入的地方民族志来实现，考虑到所有社区成员和影响者的意见，并通过深入的个人访谈和焦点小组来补充。
