Matias-Guiu Jordi A, Pytel Vanesa, Hernández-Lorenzo Laura, Patel Nikil, Peterson Katie A, Matías-Guiu Jorge, Garrard Peter, Cuetos Fernando
Department of Neurology, Hospital Clinico San Carlos, Health Research Institute "San Carlos" (IdISCC), Universidad Complutense de Madrid, Madrid, Spain.
Molecular and Clinical Science Research Institute, St George's, University of London, London, United Kingdom.
J Alzheimers Dis. 2021;83(2):771-778. doi: 10.3233/JAD-210668.
Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main clinical variants: non-fluent, semantic, and logopenic. Clinical diagnosis and accurate classification are challenging and often time-consuming. The Mini-Linguistic State Examination (MLSE) has been recently developed as a short language test to specifically assess language in neurodegenerative disorders.
Our aim was to adapt and validate the Spanish version of MLSE for PPA diagnosis.
Cross-sectional study involving 70 patients with PPA and 42 healthy controls evaluated with the MLSE. Patients were independently diagnosed and classified according to comprehensive cognitive evaluation and advanced neuroimaging.
Internal consistency was 0.758. The influence of age and education was very low. The area under the curve for discriminating PPA patients and healthy controls was 0.99. Effect sizes were moderate-large for the discrimination between PPA and healthy controls. Motor speech, phonology, and semantic subscores discriminated between the three clinical variants. A random forest classification model obtained an F1-score of 81%for the three PPA variants.
Our study provides a brief and useful language test for PPA diagnosis, with excellent properties for both clinical routine assessment and research purposes.
原发性进行性失语（PPA）是一种神经退行性综合征，有三种主要临床变体：非流利型、语义型和音韵性。临床诊断和准确分类具有挑战性，且往往耗时。迷你语言状态检查（MLSE）最近被开发出来，作为一种简短的语言测试，专门用于评估神经退行性疾病中的语言能力。
我们的目的是改编并验证用于PPA诊断的西班牙语版MLSE。
一项横断面研究，纳入70例PPA患者和42名健康对照，用MLSE进行评估。根据综合认知评估和高级神经影像学对患者进行独立诊断和分类。
内部一致性为0.758。年龄和教育程度的影响非常小。区分PPA患者和健康对照的曲线下面积为0.99。PPA与健康对照之间的区分效应大小为中等至大。运动性言语、音系学和语义子分数在三种临床变体之间存在差异。一个随机森林分类模型对三种PPA变体的F1分数为81%。
我们的研究为PPA诊断提供了一种简短且有用的语言测试，在临床常规评估和研究目的方面均具有出色的特性。
