Herrera Elena, Acevedo Claudia, González-Nosti María
Department of Psychology, University of Oviedo, 33003 Oviedo, Spain.
Geriatrics (Basel). 2024 Dec 26;10(1):2. doi: 10.3390/geriatrics10010002.
Primary progressive aphasia (PPA) is a clinical syndrome characterized by a progressive deterioration in language and speech. It is classified into three variants based on symptom patterns: logopenic, semantic, and non-fluent. Due to the lack of fully reliable and valid screening tests for diagnosing PPA and its variants, a Spanish version of the Mini Linguistic State Examination (MLSE) has recently been introduced. This study aimed to describe the language impairments in a small sample of six patients with PPA and classify them into the three variants using the decision tree and syndrome guide proposed by the MLSE authors. The findings demonstrate the test's utility in classifying some PPA variants through a qualitative analysis of patient performance and error types. The study revealed a 50% accuracy rate for the decision tree and an 83.33% accuracy rate when using the syndrome guide. This discrepancy arises because the decision tree often classified cases as logopenic variant PPA (lvPPA) when working memory was significantly impaired. Specifically, it tended to misclassify patients with semantic, motor, or speech impairments as having lvPPA due to its reliance on the sentence repetition task for assessing working memory.
原发性进行性失语（PPA）是一种以语言和言语进行性恶化为特征的临床综合征。根据症状模式，它可分为三种类型：音韵性、语义性和非流畅性。由于缺乏用于诊断PPA及其类型的完全可靠和有效的筛查测试，最近引入了西班牙语版的迷你语言状态检查（MLSE）。本研究旨在描述一小群6名PPA患者的语言障碍，并使用MLSE作者提出的决策树和综合征指南将他们分为三种类型。研究结果表明，通过对患者表现和错误类型的定性分析，该测试在对某些PPA类型进行分类方面具有实用性。研究发现，决策树的准确率为50%，使用综合征指南时的准确率为83.33%。出现这种差异的原因是，当工作记忆严重受损时，决策树经常将病例分类为音韵性变异型PPA（lvPPA）。具体而言，由于其依赖句子重复任务来评估工作记忆，它往往会将有语义、运动或言语障碍的患者误分类为患有lvPPA。
