Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181-UCCS, Unité de Catalyse et Chimie du Solide, 59000, Lille, France.
Département de Chimie, Université de Montréal, CP 6128 Succursale Centre-Ville, H3C3J7, Montréal, Québec, Canada.
ChemMedChem. 2021 Jul 20;16(14):2223-2230. doi: 10.1002/cmdc.202100030. Epub 2021 May 21.
We present the development of surfactant-free, silica-free and fully biobased oil-in-water antimicrobial Pickering emulsions, based on the self-assembly of β-cyclodextrin and phytoantimicrobial oils (terpinen-4-ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio-based drug to treat fungal infection, but is less effective than petroleum-based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram-positive and Gram-negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin-resistant S. aureus (MRSA), compared to UA and azole-based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans. Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental-friendly emulsion.
我们提出了一种基于β-环糊精和植物抗菌油（松油醇或香芹酚）自组装的无表面活性剂、无硅、完全生物基的油包水型抗菌 Pickering 乳液的开发。蓖麻油衍生的十一烯酸（UA）可用作治疗真菌感染的生物基药物，但抗菌效果不如唑类衍生物等石油基药物。为了最大限度地发挥其抗真菌潜力，我们将 UA 纳入了完全生物基的 Pickering 乳液中。这些乳液对真菌、革兰氏阳性菌和革兰氏阴性菌均有效果。与 UA 和基于唑类的商业制剂相比，带 UA 的香芹酚乳液对耐甲氧西林金黄色葡萄球菌（MRSA）的杀菌活性提高了+390%和+165%。此外，与 UA 软膏相比，该乳液对白色念珠菌的杀菌效率提高了+480%。最后，该环保型乳液对大肠杆菌和 MRSA 生物膜具有显著的清除效果。
