Lazure C, Saayman H S, Naudé R J, Oelofsen W, Chrétien M
Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Canada.
Int J Pept Protein Res. 1987 Nov;30(5):634-45. doi: 10.1111/j.1399-3011.1987.tb03374.x.
The neurohypophyseal hormones vasopressin and oxytocin are known to be synthesized in eutherian mammals as part of larger precursors containing either MSEL- or VLDV-neurophysins. A neurophysin has been isolated from ostrich neurohypophyses and shown by partial amino acid sequence determination to be related to mammalian VLDV-neurophysin. The present report describes the complete amino acid sequence of this ostrich neurophysin containing 93 residues. This amino acid sequence, the first reported in birds, differs in a remarkable manner from its mammalian homolog. Indeed, it contains a large number of substitutions, including one insertion, distributed throughout the polypeptide chain when compared to known VLDV-neurophysins. Whereas many of these substitutions are localized inside the so-called constant region of the neurophysin, the highest variation can be found in the COOH-terminal region.
已知神经垂体激素抗利尿激素和催产素在真兽类哺乳动物中作为包含MSEL-或VLDV-神经垂体素的较大前体的一部分而合成。一种神经垂体素已从鸵鸟神经垂体中分离出来，通过部分氨基酸序列测定表明它与哺乳动物的VLDV-神经垂体素有关。本报告描述了这种含有93个残基的鸵鸟神经垂体素的完整氨基酸序列。这个氨基酸序列是鸟类中首次报道的，与其哺乳动物同源物有显著差异。实际上，与已知的VLDV-神经垂体素相比，它包含大量的替换，包括一个插入，分布在整个多肽链中。虽然这些替换中的许多位于神经垂体素所谓的恒定区内，但最高的变异可以在COOH末端区域发现。
