Chauvet M T, Lévy B, Michel G, Chauvet J, Acher R
Biosci Rep. 1986 Apr;6(4):381-5. doi: 10.1007/BF01116425.
Precursors of neurohypophysial hormones are small proteins processed into nonapeptide hormones and neurophysins during axonal transport to the neurohypophysis. In mammals, oxytocin is associated with VLDV-neurophysin and vasopressin with MSEL-neurophysin. In birds, mesotocin and vasotocin are found instead of mammalian oxytocin and vasopressin. From goose, chicken and ostrich posterior pituitary glands, two types of neurophysins related to mammalian VLDV- and MSEL-neurophysins, respectively, have been identified by their N-terminal sequences. It is assumed that, as in mammals, hormonal peptide and the first 9 residues of the corresponding neurophysin are encoded by a common exon and that mesotocin and vasotocin, evolutionary predecessors of oxytocin and vasopressin, are associated in the precursors with VLDV-neurophysin and MSEL-neurophysin, respectively.
神经垂体激素的前体是小蛋白质，在轴突运输至神经垂体的过程中加工成九肽激素和神经垂体素。在哺乳动物中，催产素与VLDV-神经垂体素相关，抗利尿激素与MSEL-神经垂体素相关。在鸟类中，发现的是中催产素和加压催产素，而非哺乳动物的催产素和抗利尿激素。从鹅、鸡和鸵鸟的垂体后叶中，通过其N端序列分别鉴定出了两种与哺乳动物VLDV-和MSEL-神经垂体素相关的神经垂体素。据推测，与哺乳动物一样，激素肽和相应神经垂体素的前9个残基由一个共同的外显子编码，并且中催产素和加压催产素作为催产素和抗利尿激素的进化前身，在前体中分别与VLDV-神经垂体素和MSEL-神经垂体素相关。
