固相肽合成中的4-甲氧基苄氧羰基氨基酸

4-Methoxybenzyloxycarbonyl amino acids in solid phase peptide synthesis.

作者信息

Wang S S, Chen S T, Wang K T, Merrifield R B

机构信息

Alpha 1 Biomedicals, Inc., Foster City, California.

出版信息

Int J Pept Protein Res. 1987 Nov;30(5):662-7. doi: 10.1111/j.1399-3011.1987.tb03377.x.

DOI:10.1111/j.1399-3011.1987.tb03377.x

PMID:3436702

Abstract

Moz-amino acids were used in solid-phase synthesis of Leu-Ala-Gly-Val and thymosin alpha 1. It was found that the Moz-group can be removed rapidly and completely with 5-10% TFA in CH2Cl2. Some advantages of utilizing Moz-amino acids over Boc-amino acids in solid phase peptide synthesis are demonstrated.

摘要

莫兹氨基酸用于亮氨酸 - 丙氨酸 - 甘氨酸 - 缬氨酸和胸腺素α1的固相合成。结果发现，在二氯甲烷中用5 - 10%的三氟乙酸可快速、完全地除去莫兹基团。展示了在固相肽合成中使用莫兹氨基酸相对于叔丁氧羰基氨基酸的一些优势。