Neonatal/Pediatric Intensive Care Unit, Children's Medical Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
Front Immunol. 2021 Jul 22;12:712556. doi: 10.3389/fimmu.2021.712556. eCollection 2021.
Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all organisms. PARPs play important roles in various cellular functions, including regulating chromatin structure, transcription, replication, recombination, and DNA repair. Several studies have recently converged on the widespread involvement of PARPs and ADP-Ribosylation reaction in mammalian innate immunity. Here, we provide an overview of the emerging roles of PARPs family and ADP-ribosylation in regulating the host's innate immune responses involved in cancers, pathogenic infections, and inflammations, which will help discover and design new molecular targets for cancers, pathogenic infections, and inflammations.
多聚（腺苷二磷酸核糖）聚合酶（PARPs）是一类负责将 ADP-核糖基转移到靶蛋白上以启动 ADP-核糖基化的蛋白质，ADP-核糖基化是所有生物中高度保守和基本的翻译后修饰。PARPs 在各种细胞功能中发挥重要作用，包括调节染色质结构、转录、复制、重组和 DNA 修复。最近的几项研究表明，PARPs 和 ADP-核糖基化反应广泛参与哺乳动物先天免疫。在这里，我们提供了 PARPs 家族和 ADP-核糖基化在调节涉及癌症、病原感染和炎症的宿主先天免疫反应中的新作用的概述，这将有助于发现和设计癌症、病原感染和炎症的新分子靶标。
