Xu Yue, Zhang Wan-Xia, Wang Li-Na, Ming Yue-Qing, Li Yu-Lin, Ni Guo-Xin
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China.
World J Stem Cells. 2021 Jul 26;13(7):753-775. doi: 10.4252/wjsc.v13.i7.753.
Tendon-bone insertion injuries such as rotator cuff and anterior cruciate ligament injuries are currently highly common and severe. The key method of treating this kind of injury is the reconstruction operation. The success of this reconstructive process depends on the ability of the graft to incorporate into the bone. Recently, there has been substantial discussion about how to enhance the integration of tendon and bone through biological methods. Stem cells like bone marrow mesenchymal stem cells (MSCs), tendon stem/progenitor cells, synovium-derived MSCs, adipose-derived stem cells, or periosteum-derived periosteal stem cells can self-regenerate and potentially differentiate into different cell types, which have been widely used in tissue repair and regeneration. Thus, we concentrate in this review on the current circumstances of tendon-bone healing using stem cell therapy.
肌腱-骨附着点损伤，如肩袖损伤和前交叉韧带损伤，目前极为常见且严重。治疗这类损伤的关键方法是重建手术。这种重建过程的成功取决于移植物与骨融合的能力。最近，关于如何通过生物学方法增强肌腱与骨的融合，已经有了大量讨论。像骨髓间充质干细胞（MSCs）、肌腱干/祖细胞、滑膜来源的间充质干细胞、脂肪来源的干细胞或骨膜来源的骨膜干细胞等干细胞能够自我更新，并有可能分化为不同的细胞类型，已被广泛应用于组织修复和再生。因此，在本综述中，我们聚焦于使用干细胞疗法促进肌腱-骨愈合的现状。
