Reksodiputro M H, Hutauruk S M, Koento T, Fardizza F, Hakim R Y R, Audindra S, Yosia M
Facial Plastic Reconstructive Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia.
Larynx Pharynx Division, Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia.
Ann Med Surg (Lond). 2021 Jul 16;68:102564. doi: 10.1016/j.amsu.2021.102564. eCollection 2021 Aug.
The vocal cord in humans is essential in producing voice used in communication and interaction between us. Vocal cord paralysis causes dysphonia, which interferes with communication, causing disruptions towards social activity and daily activities. One of the managements for vocal cord paralysis is medialization and augmentation of the vocal cord through injection laryngoplasty. Autologous fat is one of the best fillers used in this procedure, but it is highly absorbable and can be reabsorbed very quickly when injected into body tissues. Platelet Rich Fibrin (PRF) is a biomaterial consisting of growth factors that are thought to improve fat tissue viability by increasing adipogenesis and angiogenesis. Improvement in fat viability will improve clinical outcomes after the laryngoplasty procedure, potentially reducing the number of repeated injections needed to achieve a satisfactory resolution to vocal cord paralysis. The study evaluates a combination of PRF and autologous microlobular fat compared with autologous microlobular fat alone on laryngoplasty. This single-blinded randomised control trial recruit a total of 18 patients, which are then randomised into the treatment and control groups. The evaluation was done via computerized acoustic analysis/Multidimensional Voice Program (MDVP) parameters and maximum phonation time. The MDVP results and maximum phonation time in both groups showed clinical improvement after the operation with no statistically significant differences.
人类的声带对于产生用于我们之间交流和互动的声音至关重要。声带麻痹会导致发声障碍，干扰交流，对社交活动和日常活动造成干扰。声带麻痹的治疗方法之一是通过注射喉成形术使声带内移和增大。自体脂肪是该手术中使用的最佳填充物之一，但它具有高度可吸收性，注射到身体组织中时会很快被重新吸收。富含血小板纤维蛋白（PRF）是一种由生长因子组成的生物材料，据认为它可以通过增加脂肪生成和血管生成来提高脂肪组织的活力。脂肪活力的提高将改善喉成形术后的临床效果，有可能减少为使声带麻痹得到满意解决所需的重复注射次数。该研究评估了PRF与自体微小叶脂肪联合使用与单独使用自体微小叶脂肪在喉成形术中的效果。这项单盲随机对照试验共招募了18名患者，然后将他们随机分为治疗组和对照组。通过计算机声学分析/多维语音程序（MDVP）参数和最长发声时间进行评估。两组的MDVP结果和最长发声时间在术后均显示出临床改善，且无统计学显著差异。
