Zheng Yi-Rong, Lei Yu-Qing, Liu Jian-Feng, Wu Hong-Lin, Xu Ning, Huang Shu-Ting, Cao Hua, Chen Qiang
Department of Cardiac Surgery, Fujian Branch of Shanghai Children's Medical Center, Fuzhou, China.
Fujian Children's Hospital, Fuzhou, China.
Front Cardiovasc Med. 2021 Jul 22;8:675213. doi: 10.3389/fcvm.2021.675213. eCollection 2021.
This study aimed to evaluate the effects of pulmonary surfactant (PS) combined with high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in infants with acute respiratory distress syndrome (ARDS) after congenital cardiac surgery. A total of 61 infants with ARDS were eligible and were randomised to the CMV + PS group ( = 30) or the HFOV + PS group ( = 31) between January 2020 and December 2020. The primary outcomes were the changes in arterial blood gas parameters. The duration of mechanical ventilation, length of hospitalisation and the incidence of complications were considered secondary outcomes. A total of 61 infants completed the study. In the HFOV + PS group, the blood gas analysis results were significantly improved ( < 0.05), while the duration of mechanical ventilation and length of hospitalisation were shorter than the CMV + PS group ( < 0.05). However, the incidence of complications was not different between the two groups ( > 0.05). Compared with the CMV + PS group, the HFOV + PS group showed significantly improved ABG variables and had a shortened length of hospitalisation and mechanical ventilation in infants with ARDS after cardiac surgery. Chinese Clinical Trial Registry; Number: ChiCTR2000039457.
本研究旨在评估肺表面活性物质（PS）联合高频振荡通气（HFOV）或传统机械通气（CMV）对先天性心脏手术后急性呼吸窘迫综合征（ARDS）婴儿的影响。2020年1月至2020年12月期间，共有61例ARDS婴儿符合条件，并被随机分为CMV + PS组（n = 30）或HFOV + PS组（n = 31）。主要结局为动脉血气参数的变化。机械通气时间、住院时间和并发症发生率被视为次要结局。共有61例婴儿完成了研究。在HFOV + PS组中，血气分析结果显著改善（P < 0.05），而机械通气时间和住院时间短于CMV + PS组（P < 0.05）。然而，两组之间的并发症发生率没有差异（P > 0.05）。与CMV + PS组相比，HFOV + PS组在心脏手术后ARDS婴儿中显示出显著改善的ABG变量，并且缩短了住院时间和机械通气时间。中国临床试验注册中心；注册号：ChiCTR2000039457。
