针对ITK信号传导治疗T细胞介导的疾病。
Targeting ITK signaling for T cell-mediated diseases.
作者信息
Weeks Samuel, Harris Rebecca, Karimi Mobin
机构信息
Department of Microbiology and Immunology, SUNY Upstate Medical University, 766 Irving Avenue Weiskotten Hall Suite 2281, Syracuse, NY 13210, USA.
出版信息
iScience. 2021 Jul 14;24(8):102842. doi: 10.1016/j.isci.2021.102842. eCollection 2021 Aug 20.
The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.
本综述的重点是研究ITK信号在多种疾病中的作用，并探讨抑制ITK的临床潜力。所综述的疾病和潜在干预措施包括T细胞源性恶性肿瘤以及其他肿瘤性疾病、哮喘和特应性皮炎等过敏性疾病、某些感染性疾病、类风湿性关节炎和银屑病等几种自身免疫性疾病，最后是实体器官和骨髓移植受者中ITK抑制的应用。
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