采用反相液相色谱法测定阿司匹林和水杨酸。
Determination of aspirin and salicylic acid by reverse-phase liquid chromatography.
作者信息
Heidemann D R, Schulenberg E S, Smith W H
机构信息
Sandoz Consumer Health Care Group (Sandoz Pharmaceuticals Corp.), Analytical Research Department, Lincoln, NE 68501-3288.
出版信息
J Assoc Off Anal Chem. 1987 Nov-Dec;70(6):964-6.
Buffered solid dosage forms containing aspirin, magnesium hydroxide, and aluminum hydroxide are blended with acidic ethanol to extract the aspirin and salicylic acid rapidly. The resulting preparation is then immediately injected onto a 4.6 mm x 3 cm 5 micron reverse-phase column. Aspirin and free salicylic acid are determined simultaneously. The run time is less than 2 min. The total time from the initiation of sample extraction to completion of the separation is less than 5 min.
含有阿司匹林、氢氧化镁和氢氧化铝的缓冲固体剂型与酸性乙醇混合，以快速提取阿司匹林和水杨酸。然后将所得制剂立即注入4.6毫米×3厘米、5微米的反相柱中。同时测定阿司匹林和游离水杨酸。运行时间不到2分钟。从开始样品提取到分离完成的总时间不到5分钟。
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