血液透析相关感染：用头孢匹林治疗
Hemodialysis-associated infections: treatment with cephapirin.
作者信息
Berman S J, Boughton W H, Sugihara J G, Wong E G, Siemsen A W
出版信息
Antimicrob Agents Chemother. 1978 Jan;13(1):4-6. doi: 10.1128/AAC.13.1.4.
Abstract
Large doses of cephapirin (50 mg/kg) administered during the first and last half hours of routine hemodialysis produced effective antimicrobial serum concentrations for 48 h. Repetitive administration during five successive hemodialysis sessions did not result in accumulation or accelerated metabolism of cephapirin. Ten infectious episodes in nine patients were treated in this manner with good clinical results and no toxicity.
摘要
在常规血液透析的最初半小时和最后半小时给予大剂量头孢匹林（50毫克/千克），可产生有效的抗菌血清浓度，持续48小时。在连续五次血液透析疗程中重复给药，未导致头孢匹林蓄积或代谢加速。九名患者发生的十次感染发作均以此方式治疗，临床效果良好，且无毒性。
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The cephalosporins. Microbiological, chemical, and pharmacological properties and use in chemotherapy of infection.头孢菌素。微生物学、化学及药理学特性以及在感染化疗中的应用。
Ann Intern Med. 1970 May;72(5):729-39. doi: 10.7326/0003-4819-72-5-729.
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Adverse reactions to cephalothin and cephapirin. Uniform occurrence on prolonged intravenous administration of high doses.头孢噻吩和头孢匹林的不良反应。大剂量长时间静脉给药时均会出现。
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