Naveh Y, Strahovsky P, Friedman A
Arch Dis Child. 1977 Dec;52(12):960-1. doi: 10.1136/adc.52.12.960.
Eleven infants aged 1-2 years suffering from shigellosis associated with Shigella flexneri type 6 were treated with rifampicin. All were initially treated with antimicrobial drugs to which Sh. flexneri was shown to be sensitive, but without effect. Rifampicin was effective in curing gastrointestinal symptoms and eradicating the bacilli in all infants in 5 days. The drug was given in a dose of 10-12 mg/kg per day divided into two equal parts, for 7 days. No untoward side effects were observed. Our experience should encourage the use of this agent in controlling outbreaks of shigellosis and in curing resistant Shigella spp. infections where other antimicrobial agents prove to be inefficient.
11名1至2岁患6型福氏志贺菌所致志贺氏菌病的婴儿接受了利福平治疗。所有婴儿最初均接受了对福氏志贺菌显示敏感的抗菌药物治疗，但无效。利福平在5天内有效治愈了所有婴儿的胃肠道症状并根除了杆菌。该药剂量为每日10 - 12mg/kg，分两等份服用，共7天。未观察到不良副作用。我们的经验应促使在控制志贺氏菌病暴发以及治疗其他抗菌药物证明无效的耐药志贺氏菌属感染时使用该药物。
