舒林酸。一种新型抗炎药物的试验。
Sulindac. Trials of a new anti-inflammatory drug.
作者信息
Huskisson E C, Scott J
出版信息
Ann Rheum Dis. 1978 Feb;37(1):89-92. doi: 10.1136/ard.37.1.89.
Abstract
Trials in patients with rheumatoid arthritis and osteoarthritis showed sulindac to be an analgesic with anti-inflammatory properties and at least as effective as aspirin. It was effective within 24 hours in doses of 300-400 mg daily. It had the advantages of twice daily administration and a lower incidence of gastric side effects than aspirin. Constipation, usually mild, occurred in 20-30% of cases. Like other anti-inflammatory drugs, it was effective in only a proportion of the patients.
摘要
针对类风湿性关节炎和骨关节炎患者的试验表明，舒林酸是一种具有抗炎特性的镇痛药，其疗效至少与阿司匹林相当。每日剂量为300 - 400毫克时，24小时内即可起效。它具有每日给药两次的优点，且胃部副作用的发生率低于阿司匹林。便秘通常较轻，在20% - 30%的病例中出现。与其他抗炎药一样，它仅对一部分患者有效。
相似文献
1
Sulindac. Trials of a new anti-inflammatory drug.舒林酸。一种新型抗炎药物的试验。
Ann Rheum Dis. 1978 Feb;37(1):89-92. doi: 10.1136/ard.37.1.89.
2
Comparison of sulindac and aspirin in rheumatoid arthritis.
Curr Med Res Opin. 1977;4(7):485-91. doi: 10.1185/03007997709109337.
3
[Treatment of chronic polyarthritis with Sulindac].
MMW Munch Med Wochenschr. 1977 Oct 21;119(42):1369-70.
4
[Sulindac: Clinical test of a new antiinflammatory agent in rheumatoid arthritis (author's transl)].
Wien Klin Wochenschr Suppl. 1976;59:1-10.
5
Clinical trials of Sulindac in rheumatoid and osteoarthritis.
Acta Rhumatol Belg. 1977 Jul-Dec;1(3-4):257-61.
6
[Experience with sulindac in rheumatoid arthritis and osteoarthritis].[舒林酸治疗类风湿性关节炎和骨关节炎的经验]
Reumatizam. 1980;27(2):35-7.
7
A controlled clinical study comparing sulindac with ibuprofen and aspirin in the treatment of musculo-skeletal diseases.
J Int Med Res. 1979;7(6):556-9. doi: 10.1177/030006057900700615.
8
Sulindac: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Drugs. 1978 Aug;16(2):97-114. doi: 10.2165/00003495-197816020-00001.
9
A comparison of benoxaprofen and sulindac in patients with rheumatoid arthritis and osteoarthritis.类风湿性关节炎和骨关节炎患者中苯恶洛芬与舒林酸的比较。
Eur J Rheumatol Inflamm. 1982;5(2):258-69.
10
A multicenter trial of sulindac in osteoarthritis of the hip.
Clin Pharmacol Ther. 1977 Sep;22(3):358-63. doi: 10.1002/cpt1977223358.
引用本文的文献
1
Studies on the metabolism and biological activity of the epimers of sulindac.舒林酸差向异构体的代谢和生物学活性研究。
Drug Metab Dispos. 2011 Jun;39(6):1014-21. doi: 10.1124/dmd.110.037663. Epub 2011 Mar 7.
2
An objective measurement of change in morning stiffness.
Rheumatol Int. 1981;1(3):135-7. doi: 10.1007/BF00541258.
3
Variations in responses to non-steroidal anti-inflammatory drugs.对非甾体抗炎药反应的差异。
Br J Clin Pharmacol. 1982 Nov;14(5):691-4. doi: 10.1111/j.1365-2125.1982.tb04958.x.
4
Antirheumatic drugs: clinical pharmacology and therapeutic use.抗风湿药物：临床药理学与治疗应用。
Drugs. 1980 Dec;20(6):453-84. doi: 10.2165/00003495-198020060-00002.
5
Outcome measurement in osteoarthritis clinical trials: the case for standardisation.骨关节炎临床试验中的疗效评估：标准化的必要性
Clin Rheumatol. 1984 Sep;3(3):293-303. doi: 10.1007/BF02032334.
6
Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.
Ann Rheum Dis. 1978 Aug;37(4):389. doi: 10.1136/ard.37.4.389-a.
7
Sulindac: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
Drugs. 1978 Aug;16(2):97-114. doi: 10.2165/00003495-197816020-00001.
本文引用的文献
1
2
Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis.水杨酸酯类药物在类风湿关节炎中抗炎作用的临床测量
Br Med J. 1967 Nov 4;4(5574):264-8. doi: 10.1136/bmj.4.5574.264.
3
Physiologic disposition and metabolic fate of a new anti-inflammatory agent, cis-5-fluro-2-methyl-1-(p-(methylsulfinyl)-benzylidenyl)-indene-3-acetic acid in the rat, dog, rhesus monkey, and man.一种新型抗炎药顺式-5-氟-2-甲基-1-（对-（甲基亚磺酰基）-亚苄基）-茚-3-乙酸在大鼠、狗、恒河猴和人体内的生理处置及代谢命运
Drug Metab Dispos. 1973 Nov-Dec;1(6):721-36.
4
[Proceedings: Double-blind comparison of MK 231 with indomethacin in spondylitis ankylopoetica].
Ned Tijdschr Geneeskd. 1975 Jul 12;119(28):1135.
5
Sulindac in osteoarthrosis of the hip.
Rheumatol Rehabil. 1976 May;15(2):112-5. doi: 10.1093/rheumatology/15.2.112.
Zotero 插件