舒林酸与阿司匹林在类风湿性关节炎中的比较。

Comparison of sulindac and aspirin in rheumatoid arthritis.

作者信息

Reynolds P M, Rhymer A R, MacLeod M M, Buchanan W W

出版信息

Curr Med Res Opin. 1977;4(7):485-91. doi: 10.1185/03007997709109337.

Abstract

Thirty-one out-patients with rheumatoid arthritis took part in a 10 week double-blind comparison of sulindac (cis-5-fluoro-2-methyl-1-[p-(methylsulphinyl)-benzylidene]-indene-3-acetic acid) 200 mg twice daily and aspirin 3.6 g daily, with a 2-week placebo control period. Both drugs were superior to placebo. The incidence of side-effects was approximately the same on the two drugs, but there was a higher drop-out rate due to side-effects on aspirin.

摘要

31名类风湿性关节炎门诊患者参与了一项为期10周的双盲比较试验，试验中患者被分为两组，一组每日两次服用200毫克舒林酸（顺式-5-氟-2-甲基-1-[对-(甲基亚磺酰基)-亚苄基]-茚-3-乙酸），另一组每日服用3.6克阿司匹林，同时设有为期2周的安慰剂对照期。两种药物的疗效均优于安慰剂。两种药物的副作用发生率大致相同，但因阿司匹林副作用导致的退出率更高。