Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Gut Liver. 2022 May 15;16(3):384-395. doi: 10.5009/gnl210141.
BACKGROUND/AIMS: Improving quality of life has been gaining importance in ulcerative colitis (UC) management. The aim of this study was to investigate changes in health-related quality of life (HRQL) and related factors in patients with moderate-to-severe UC.
A multicenter, hospital-based, prospective study was performed using a Moderate-to-Severe Ulcerative Colitis Cohort in Korea (the MOSAIK). Changes in HRQL, evaluated using the 12-Item Short Form Health Survey (SF-12) and Inflammatory Bowel Disease Questionnaire (IBDQ), were analyzed at the time of diagnosis and 1 year later.
In a sample of 276 patients, the mean age was 38.4 years, and the majority of patients were male (59.8%). HRQL tended to increase in both the IBDQ and SF-12 1 year after diagnosis. A higher partial Mayo score was significantly related to poorer HRQL on the IBDQ and SF-12 in a linear mixed model (p<0.01). Inflammatory markers such as C-reactive protein (CRP) or erythrocyte sedimentation rate also showed a negative correlation on HRQL (p<0.05). Patients whose IBDQ score improved by 16 or more (71.2%) in 1 year were younger, tended to be nonsmokers, and had a lower partial Mayo score and CRP than those whose IBDQ score did not. There was no significant association between HRQL and disease extent, treatments at diagnosis, or the highest treatment step during the 1-year period.
Optimally controlled disease status improves HRQL in patients with moderate-to-severe UC. The partial Mayo score and inflammatory markers may be potential indicators reflecting the influence of UC on patient`s daily lives.
背景/目的：提高生活质量在溃疡性结肠炎（UC）的治疗中越来越受到重视。本研究旨在调查中重度 UC 患者健康相关生活质量（HRQL）的变化及其相关因素。
采用韩国中重度溃疡性结肠炎队列（MOSAIK）进行多中心、基于医院的前瞻性研究。使用 12 项简明健康调查问卷（SF-12）和炎症性肠病问卷（IBDQ）评估患者在诊断时和 1 年后的 HRQL 变化。
在 276 例患者的样本中，平均年龄为 38.4 岁，大多数患者为男性（59.8%）。HRQL 在 IBDQ 和 SF-12 上均呈上升趋势。线性混合模型显示，较高的部分 Mayo 评分与 IBDQ 和 SF-12 上的 HRQL 较差显著相关（p<0.01）。炎症标志物如 C 反应蛋白（CRP）或红细胞沉降率也与 HRQL 呈负相关（p<0.05）。在 1 年内 IBDQ 评分改善 16 分或更多的患者（71.2%）更年轻，往往不吸烟，且部分 Mayo 评分和 CRP 较低。在 1 年内，HRQL 与疾病程度、诊断时的治疗、或最高治疗步骤均无显著相关性。
疾病得到最佳控制可改善中重度 UC 患者的 HRQL。部分 Mayo 评分和炎症标志物可能是反映 UC 对患者日常生活影响的潜在指标。
