丹麦基于人群的发病队列中炎症性肠病的健康相关生活质量。
Health-related quality of life in inflammatory bowel disease in a Danish population-based inception cohort.
机构信息
Gastrounit, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Medical Department, Zealand University Hospital, Koege, Denmark.
出版信息
United European Gastroenterol J. 2019 Aug;7(7):942-954. doi: 10.1177/2050640619852532. Epub 2019 May 17.
BACKGROUND
Crohn's disease (CD) and ulcerative colitis (UC) are associated with reduced health-related quality of life (HRQoL), but findings differ between studies. The aim of this study was to analyse the impact of disease activity and social factors on HRQoL.
METHOD
A total of 513 patients diagnosed with UC and CD between 2003 and 2004, in a population-based setting, were followed for 7 years. HRQoL was assessed using the Short Form-12, the Short Inflammatory Bowel Disease (IBD) Questionnaire (SIBDQ), the Work Productivity and Activity Impairment Questionnaire: General Health and a national health survey. Associations were assessed using multiple linear regressions.
RESULTS
A total of 185 of the eligible patients (UC: 107 (50.2%) and CD: 78 (50.3%)) were included. No differences in disease-specific or generic HRQoL were found between CD and UC patients, and IBD patients did not differ compared with the background population. The majority of CD (73.1%) and UC (85.0%) patients had 'good' disease-specific HRQoL using the SIBDQ. Unemployment for ≥ 3 months occurred more in CD vs UC patients(30.6 vs 15.5%, = 0.03); however, sick leave for ≥ 3 months did not differ significantly (17.4 vs 11.4%, = 0.4). Using multiple linear regressions, unemployment, sick leave and disease activity were the factors most frequently associated with reduced HRQoL.
CONCLUSION
In a population-based cohort with 7 years of follow-up, HRQoL did not differ between patients and the background population.
背景
克罗恩病（CD）和溃疡性结肠炎（UC）与健康相关生活质量（HRQoL）降低有关，但研究结果存在差异。本研究旨在分析疾病活动度和社会因素对 HRQoL 的影响。
方法
在基于人群的环境中，于 2003 年至 2004 年期间诊断为 UC 和 CD 的 513 名患者，随访 7 年。使用 12 项简短健康调查问卷（SF-12）、简短炎症性肠病问卷（SIBDQ）、工作效率和活动障碍问卷：一般健康状况和全国健康调查来评估 HRQoL。使用多元线性回归来评估相关性。
结果
符合条件的 185 名患者（UC：107（50.2%）和 CD：78（50.3%））被纳入研究。CD 和 UC 患者的疾病特异性或一般 HRQoL 无差异，且 IBD 患者与背景人群无差异。使用 SIBDQ，大多数 CD（73.1%）和 UC（85.0%）患者的疾病特异性 HRQoL 良好。与 UC 患者相比，CD 患者失业（≥3 个月）的比例更高（30.6%对 15.5%，=0.03）；然而，病假（≥3 个月）的比例无显著差异（17.4%对 11.4%，=0.4）。使用多元线性回归，失业、病假和疾病活动度是与 HRQoL 降低最相关的因素。
结论
在一项基于人群的队列研究中，随访 7 年后，患者的 HRQoL 与背景人群无差异。
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