Department of Diabetes and Endocrinology, Akashi Medical Center Hospital, Japan.
Department of General Internal Medicine, Akashi Medical Center Hospital, Japan.
Intern Med. 2022 Feb 1;61(3):365-371. doi: 10.2169/internalmedicine.7663-21. Epub 2021 Aug 6.
A 21-year-old Japanese man without known diabetes mellitus had abdominal pain. The diagnosis was ketoacidosis and hypertriglyceridemia-induced acute pancreatitis. He had polydipsia and polyuria and had habitually drunk several soft drinks every day for two years. After hospitalization, despite adequate liquid intake, dehydration remained with hypotonic polyuria. Further examinations revealed the coexistence of central diabetes insipidus (CDI), possibly caused by lymphocytic infundibulo-neurohypophysitis, based on anti-rabphilin-3A antibody positivity. Although CDI had been undiagnosed for two years, over-consumption of sugar-rich soft drinks to ease thirst caused ketoacidosis, hypertriglyceridemia, and acute pancreatitis. There are no previous reports of this three-part combination of symptoms caused by CDI.
一位 21 岁的日本男性，无已知糖尿病病史，出现腹痛。诊断为酮症酸中毒和甘油三酯血症诱发的急性胰腺炎。他有多饮和多尿的症状，并且两年来习惯每天喝几罐软饮料。住院后，尽管液体摄入充足，但仍存在脱水和低张性多尿。进一步的检查显示，他同时存在中枢性尿崩症（CDI），可能是由淋巴细胞性漏斗神经垂体炎引起的，基于抗 rabphilin-3A 抗体阳性。尽管 CDI 已经存在两年未被诊断，但为了缓解口渴而过度摄入含糖软饮料导致了酮症酸中毒、高甘油三酯血症和急性胰腺炎。以前没有报道过这种由 CDI 引起的三联征症状。
