Division of Preemptive Medicine for Digestive Disease and Healthy Active Life, School of Medicine, Niigata University, Japan.
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.
Intern Med. 2022 Feb 1;61(3):339-344. doi: 10.2169/internalmedicine.7953-21. Epub 2021 Aug 6.
Pneumocystis jirovecii pneumonia (PJP) and cytomegalovirus (CMV) colitis are opportunistic infections that occur during immunosuppressive treatments for ulcerative colitis (UC). The prognosis of PJP and CMV colitis is very poor. We herein report a rare case of a 74-year-old UC patient with PJP and CMV colitis that was successfully treated with intensive therapy. PJP progresses rapidly, so the timing and choice of treatment are critical. Furthermore, a literature review of similar cases suggested that prophylactic therapy for opportunistic infections might be important, especially in the elderly. This case will serve as a reference for successful treatment in future cases.
肺囊虫肺炎（PJP）和巨细胞病毒（CMV）结肠炎是溃疡性结肠炎（UC）免疫抑制治疗期间发生的机会性感染。PJP 和 CMV 结肠炎的预后非常差。本文报告了一例罕见的 74 岁 UC 患者合并 PJP 和 CMV 结肠炎，经强化治疗成功治愈。PJP 进展迅速，因此治疗时机和选择至关重要。此外，对类似病例的文献回顾表明，机会性感染的预防性治疗可能很重要，尤其是在老年人中。该病例将为今后的成功治疗提供参考。
