Miki Mika, Iemoto Takao, Sanuki Tsuyoshi, Sasaki Ayaka, Tanaka Katsuhide, Yoshie Tomoo, Oose Takayuki, Morikawa Teruhisa, Yamamoto Yuki
Department of Gastroenterology, Kita-Harima Medical Center.
Department of Pathology, Kita-Harima Medical Center.
Nihon Shokakibyo Gakkai Zasshi. 2021;118(8):775-785. doi: 10.11405/nisshoshi.118.775.
A 76-year-old man presented to our hospital with continuous abdominal pain and vomiting. The results of the computed tomography indicated a pancreatic head mass with multiple liver metastatic tumors. Multiple liver tumors progressed rapidly, and the patient died of the resulting acute hepatic failure approximately 1 month after the onset of symptoms. The results of the postmortem examination indicated anaplastic pancreatic carcinoma (pleomorphic type) with multiple liver metastases. The tumor cells in the primary pancreatic lesion and liver metastases were replaced with normal tissue, and they showed a decrease in stainability by E-cadherin staining. Overall, the pathological findings suggested that the inhibition of E-cadherin may be related to the proliferation and infiltration of anaplastic cancer cells.
一名76岁男性因持续性腹痛和呕吐前来我院就诊。计算机断层扫描结果显示胰头肿块伴多发肝转移瘤。多发肝肿瘤进展迅速，患者在症状出现后约1个月死于急性肝衰竭。尸检结果显示为间变性胰腺癌（多形性类型）伴多发肝转移。原发性胰腺病变和肝转移灶中的肿瘤细胞被正常组织取代，E-钙黏蛋白染色显示其染色性降低。总体而言，病理结果提示E-钙黏蛋白的抑制可能与间变性癌细胞的增殖和浸润有关。
