Sato Kazuhide, Takeyama Yoshihiro, Tanaka Taku, Fukui Yasutaka, Gonda Hideo, Suzuki Ryujiro
The Department of Respiratory Medicine, Toyohashi Municipal Hospital, Japan.
Respir Investig. 2013 Jun;51(2):98-102. doi: 10.1016/j.resinv.2012.12.004. Epub 2013 Feb 26.
Fulminant hepatic failure (FHF) is defined as a liver disease that causes encephalopathy within 8 weeks of onset in the absence of pre-existing liver disease. Although liver metastases are commonly found in cancer patients, FHF secondary to diffuse liver infiltration is rare. Here, we report the rare autopsy cases of patients with small cell lung carcinoma (SCLC) and secondary FHF. These patients presented with remarkable hepatomegaly and a near complete replacement of the liver parenchyma with metastatic tumor. Neoplastic involvement of the liver should be considered in the differential diagnosis of FHF.
暴发性肝衰竭（FHF）被定义为一种在无既往肝病的情况下，发病8周内导致肝性脑病的肝脏疾病。尽管在癌症患者中常见肝转移，但继发于弥漫性肝浸润的FHF却很罕见。在此，我们报告小细胞肺癌（SCLC）继发FHF患者的罕见尸检病例。这些患者表现为显著肝肿大，肝实质几乎完全被转移瘤替代。在FHF的鉴别诊断中应考虑肝脏的肿瘤性累及。
