• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

美国国家老龄化研究所的种子基金使阿尔茨海默病初创企业能够达到关键的价值转折点。

National Institute on Aging seed funding enables Alzheimer's disease startups to reach key value inflection points.

机构信息

Office of Small Business Research, National Institute on Aging, Bethesda, Maryland, USA.

Office of Planning, Analysis, and Evaluation, National Institute on Aging, Bethesda, Maryland, USA.

出版信息

Alzheimers Dement. 2022 Feb;18(2):348-359. doi: 10.1002/alz.12392. Epub 2021 Aug 10.

DOI:10.1002/alz.12392
PMID:34374496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9291195/
Abstract

INTRODUCTION

The National Institute on Aging (NIA) provides funding to academic researchers and small businesses working in the Alzheimer's Disease (AD) and AD-related dementia (ADRD) fields to help commercialize their products. The NIA uses Small Business Innovation Research (SBIR) awards to bridge the funding gap in the diagnostic, therapeutic, and care interventions areas, enabling startups to reach key value inflection points to achieve scientific milestones.

METHODS

Only publicly available information is reported. The National Institutes of Health Report Portfolio Online Reporting Tool database and the commercial database Global Data, were used to track the progress of companies that received SBIR or Small Business Technology Transfer (STTR) funding from the NIA.

RESULTS

Since 2008, the NIA has awarded $280 million-including $207 million from fiscal year (FY) 2015 to FY 2019-in new small business program awards for AD/ADRD research.

DISCUSSION

NIA seed capital and mentoring programs are critical resources to help small businesses reach key value inflection points and advance their research from concept to commercialization.

摘要

简介

美国国家老龄化研究所（NIA）为从事阿尔茨海默病（AD）和相关痴呆症（ADRD）领域的学术研究人员和小企业提供资金，以帮助其将产品商业化。NIA 通过小企业创新研究（SBIR）奖项来填补诊断、治疗和护理干预领域的资金缺口，使初创企业能够达到关键的价值拐点，实现科学里程碑。

方法

仅报告了公开信息。美国国立卫生研究院报告组合在线报告工具数据库和商业数据库 Global Data 用于跟踪从 NIA 获得 SBIR 或小企业技术转让（STTR）资金的公司的进展情况。

结果

自 2008 年以来，NIA 已授予 2.8 亿美元的新小企业计划奖，用于 AD/ADRD 研究，其中包括 2015 财年至 2019 财年的 2.07 亿美元。

讨论

NIA 的种子资金和指导计划是帮助小企业达到关键价值拐点并将其研究从概念推进到商业化的重要资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/f9705bb4eb4c/ALZ-18-348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/7183a46b8265/ALZ-18-348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/9c87bc49d042/ALZ-18-348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/8c856e93640b/ALZ-18-348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/6b2358e68ccd/ALZ-18-348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/84bf6eca2e2b/ALZ-18-348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/9b8104f1a7b1/ALZ-18-348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/f9705bb4eb4c/ALZ-18-348-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/7183a46b8265/ALZ-18-348-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/9c87bc49d042/ALZ-18-348-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/8c856e93640b/ALZ-18-348-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/6b2358e68ccd/ALZ-18-348-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/84bf6eca2e2b/ALZ-18-348-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/9b8104f1a7b1/ALZ-18-348-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8018/9291195/f9705bb4eb4c/ALZ-18-348-g005.jpg

相似文献

1
National Institute on Aging seed funding enables Alzheimer's disease startups to reach key value inflection points.美国国家老龄化研究所的种子基金使阿尔茨海默病初创企业能够达到关键的价值转折点。
Alzheimers Dement. 2022 Feb;18(2):348-359. doi: 10.1002/alz.12392. Epub 2021 Aug 10.
2
Creative partnerships for funding nursing research.为护理研究筹集资金的创新伙伴关系。
West J Nurs Res. 2011 Feb;33(1):79-105. doi: 10.1177/0193945910377768. Epub 2010 Aug 18.
3
Attracting New Investigators to Alzheimer's Disease Research: Outcomes of Increased Funding and Outreach.吸引新的阿尔茨海默病研究人员：增加资金和外展的结果。
Gerontologist. 2021 Apr 3;61(3):312-318. doi: 10.1093/geront/gnaa056.
4
Geographically-related outcomes of U.S. funding for small business research and development: Results of the research grant programs of a component of the National Institutes of Health.美国小企业研发资金的地域相关成果：国立卫生研究院一个组成部分的研究资助项目结果
Eval Program Plann. 2019 Dec;77:101696. doi: 10.1016/j.evalprogplan.2019.101696. Epub 2019 Jul 31.
5
Using database linkages to measure innovation, commercialization, and survival of small businesses.利用数据库链接来衡量小企业的创新、商业化和生存情况。
Eval Program Plann. 2019 Dec;77:101710. doi: 10.1016/j.evalprogplan.2019.101710. Epub 2019 Sep 3.
6
The price of progress: Funding and financing Alzheimer's disease drug development.进步的代价：阿尔茨海默病药物研发的资金与融资
Alzheimers Dement (N Y). 2018 Jun 13;4:330-343. doi: 10.1016/j.trci.2018.04.008. eCollection 2018.
7
Investor initiatives program: Public-private partnerships to expedite commercialization for NCI-funded small business entrepreneurs.投资者倡议计划：促进 NCI 资助的小企业企业家商业化的公私合作伙伴关系。
Clin Transl Sci. 2021 Nov;14(6):2124-2131. doi: 10.1111/cts.13119. Epub 2021 Aug 13.
8
Can the SBIR and STTR programs advance research goals?小企业创新研究计划（SBIR）和小企业技术转移研究计划（STTR）能否推进研究目标？
Nat Immunol. 2013 Mar;14(3):192-5. doi: 10.1038/ni.2495.
9
Hydrocephalus research funding from the National Institutes of Health: a 10-year perspective.美国国立卫生研究院的脑积水研究资金：十年展望
J Neurosurg Pediatr. 2014 Feb;13(2):145-50. doi: 10.3171/2013.11.PEDS13197. Epub 2013 Dec 6.
10
Gender Disparity in Grants and Awards at the National Institute of Health.美国国立卫生研究院资助与奖项中的性别差异。
Cureus. 2021 Apr 23;13(4):e14644. doi: 10.7759/cureus.14644.

引用本文的文献

1
Heterogeneous treatment effects of sodium-glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population-based cohort study.钠-葡萄糖共转运蛋白 2 抑制剂对 2 型糖尿病患者痴呆风险的异质性治疗效果：基于人群的队列研究。
Alzheimers Dement. 2024 Aug;20(8):5528-5539. doi: 10.1002/alz.14048. Epub 2024 Jul 3.
2
Heterogeneous treatment effects of metformin on risk of dementia in patients with type 2 diabetes: A longitudinal observational study.二甲双胍对 2 型糖尿病患者痴呆风险的异质性治疗效果：一项纵向观察性研究。
Alzheimers Dement. 2024 Feb;20(2):975-985. doi: 10.1002/alz.13480. Epub 2023 Oct 13.
3

本文引用的文献

1
NIH funding and the pursuit of edge science.NIH 资助与前沿科学的追求。
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12011-12016. doi: 10.1073/pnas.1910160117. Epub 2020 May 19.
2
Using database linkages to measure innovation, commercialization, and survival of small businesses.利用数据库链接来衡量小企业的创新、商业化和生存情况。
Eval Program Plann. 2019 Dec;77:101710. doi: 10.1016/j.evalprogplan.2019.101710. Epub 2019 Sep 3.
3
Alzheimer's disease drug development pipeline: 2019.2019年阿尔茨海默病药物研发进程
Recruitment of family caregivers of persons with dementia: Lessons learned from a pilot randomized controlled trial.
痴呆症患者家庭照顾者的招募：一项试点随机对照试验的经验教训。
Front Pain Res (Lausanne). 2023 Mar 27;4:1125914. doi: 10.3389/fpain.2023.1125914. eCollection 2023.
4
An analysis of the Clinical and Translational Science Award pilot project portfolio using data from Research Performance Progress Reports.利用研究绩效进展报告中的数据对临床与转化科学奖试点项目组合进行分析。
J Clin Transl Sci. 2022 Aug 18;6(1):e113. doi: 10.1017/cts.2022.444. eCollection 2022.
5
A classification for complex imbalanced data in disease screening and early diagnosis.疾病筛查和早期诊断中复杂不平衡数据的分类。
Stat Med. 2022 Aug 30;41(19):3679-3695. doi: 10.1002/sim.9442. Epub 2022 May 23.
Alzheimers Dement (N Y). 2019 Jul 9;5:272-293. doi: 10.1016/j.trci.2019.05.008. eCollection 2019.
4
Tackling gaps in developing life-changing treatments for dementia.应对在开发改变痴呆症治疗方法方面存在的差距。
Alzheimers Dement (N Y). 2019 Jun 24;5:241-253. doi: 10.1016/j.trci.2019.05.001. eCollection 2019.
5
I-Corps at NIH: Entrepreneurial Training Program Creating Successful Small Businesses.美国国立卫生研究院的 I-Corps：创建成功小企业的创业培训项目。
Clin Transl Sci. 2019 Jul;12(4):324-328. doi: 10.1111/cts.12637. Epub 2019 May 6.
6
The price of progress: Funding and financing Alzheimer's disease drug development.进步的代价：阿尔茨海默病药物研发的资金与融资
Alzheimers Dement (N Y). 2018 Jun 13;4:330-343. doi: 10.1016/j.trci.2018.04.008. eCollection 2018.
7
Direct and indirect cost of managing alzheimer's disease and related dementias in the United States.美国阿尔茨海默病及相关痴呆症管理的直接和间接成本。
Expert Rev Pharmacoecon Outcomes Res. 2017 Apr;17(2):189-202. doi: 10.1080/14737167.2017.1313118.
8
Economic analysis of opportunities to accelerate Alzheimer's disease research and development.加速阿尔茨海默病研究与开发的机会的经济分析。
Ann N Y Acad Sci. 2014 Apr;1313(1):17-34. doi: 10.1111/nyas.12417. Epub 2014 Mar 27.
9
Monetary costs of dementia in the United States.美国痴呆症的货币成本。
N Engl J Med. 2013 Apr 4;368(14):1326-34. doi: 10.1056/NEJMsa1204629.
10
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census.美国阿尔茨海默病（2010-2050 年）的预估基于 2010 年的人口普查数据。
Neurology. 2013 May 7;80(19):1778-83. doi: 10.1212/WNL.0b013e31828726f5. Epub 2013 Feb 6.