Sziegoleit W, Weiss M, Fahr A, Scharfe S
Institute of Pharmacology and Toxicology, Martin Luther University, Halle, GDR.
Jpn Circ J. 1987 Nov;51(11):1305-9. doi: 10.1253/jcj.51.1305.
The influence of trapidil on serum levels and cardiac effects of digoxin was investigated in 10 healthy men, intraindividually compared with placebo. Each subject took digoxin orally for 9 days (0.375 mg daily on days 1 to 8, 0.25 mg on day 9) either combined with trapidil (400 mg daily on days 1 to 8, 200 mg on day 9) or combined with placebo in a cross-over design. Trapidil failed to change significantly the steady-state serum digoxin concentrations on day 9 of treatment. It did also not alter significantly the following digoxin effects: shortening in QS2c time indicating the cardiotonic digoxin effect, shortening in QTc time, increase in PTQ index. But trapidil prevented the negative chronotropic digoxin effect.
在10名健康男性中研究了曲匹地尔对地高辛血清水平和心脏效应的影响，并在个体内与安慰剂进行了比较。采用交叉设计，每位受试者口服地高辛9天（第1至8天每日0.375毫克，第9天0.25毫克），要么与曲匹地尔联合使用（第1至8天每日400毫克，第9天200毫克），要么与安慰剂联合使用。在治疗第9天时，曲匹地尔未能显著改变地高辛的稳态血清浓度。它也没有显著改变以下地高辛效应：QS2c时间缩短表明地高辛的强心作用，QTc时间缩短，PTQ指数增加。但曲匹地尔可防止地高辛的负性变时效应。
