曲匹地尔对戊巴比妥抑制的犬心肺制备物心脏功能的改善作用。
Improvement by trapidil of cardiac function of the dog heart-lung preparation depressed by pentobarbital.
作者信息
Satoh K, Kawada M, Taira N
出版信息
Jpn Heart J. 1983 May;24(3):399-405. doi: 10.1536/ihj.24.399.
PMID:6876384
Abstract
The effect of trapidil on depressed cardiac function was investigated in 5 dog heart-lung preparations. Trapidil at a dose of 60 mg improved cardiac function which had been severely depressed by 70 +/- 32 (S.D.) mg of sodium pentobarbital. This dose of trapidil, however, produced no significant increase in heart rate. The results suggest that trapidil would be useful in the treatment of heart failure.
摘要
在5个犬心肺制备模型中研究了曲匹地尔对心脏功能抑制的作用。60毫克剂量的曲匹地尔可改善由70±32（标准差）毫克戊巴比妥钠严重抑制的心脏功能。然而，该剂量的曲匹地尔并未使心率显著增加。结果表明，曲匹地尔可能对心力衰竭的治疗有用。
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