Institute of Pathogenic Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Health Education and Detection Center, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory for Parasitology and Vector Biology; WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai, China.
Vector Borne Zoonotic Dis. 2021 Oct;21(10):777-784. doi: 10.1089/vbz.2021.0023. Epub 2021 Aug 10.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, which has caused unprecedented damage to human health and life. The present study aimed to carry out and discover asymptomatic infected individuals in Shenzhen, China. The data will provide the control measures to stop COVID-19 prevalence. The study was a retrospective review of medical records from 462 confirmed patients with COVID-19 and 45 asymptomatic infected individuals in Shenzhen from January 19 to April 30, 2020; this is a retrospective, observational multicenter study. A total of 462 confirmed cases were diagnosed in Shenzhen from January 19 to April 30, 2020. The cohort included 423 domestic cases (91.56%, 95% confidence interval [CI]: 88.67-93.76) and 39 (8.44%, 95% CI: 6.24-11.33) imported cases from other countries. Moreover, a total of 45 asymptomatic infections were found, encompassing 31 (68.89%, 95% CI: 54.34-80.47) local infections and 14 (31.11%, 95% CI: 19.53-45.66) individuals imported from other countries. The proportion of asymptomatic infected persons in Shenzhen is continuously increasing ( = 13.19, < 0.0001). The total number of local asymptomatic infections was more than that in other provinces ( = 118.83, < 0.0001). The proportion of asymptomatic infected individuals among cases imported from other countries was higher than the domestic cases ( = 22.51, < 0.0001, odds ratio = 4.90, 95% CI: 2.40-9.98). The proportion of asymptomatic infection is increasing. Hence, development and application of the diagnosis method with high sensitivity and specificity play a critical role in reducing COVID-19 global epidemics.
新型冠状病毒病 2019（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，已成为全球大流行，对人类健康和生命造成了前所未有的破坏。本研究旨在在中国深圳发现无症状感染者。这些数据将为控制措施提供依据，以阻止 COVID-19 的流行。
该研究回顾性分析了 2020 年 1 月 19 日至 4 月 30 日期间在深圳的 462 例确诊 COVID-19 患者和 45 例无症状感染者的病历，这是一项回顾性、观察性多中心研究。
2020 年 1 月 19 日至 4 月 30 日期间，深圳共确诊 462 例病例。该队列包括 423 例国内病例（91.56%，95%置信区间[CI]：88.67-93.76）和 39 例来自其他国家的输入病例（8.44%，95% CI：6.24-11.33）。此外，共发现 45 例无症状感染，其中包括 31 例（68.89%，95% CI：54.34-80.47）本地感染和 14 例（31.11%，95% CI：19.53-45.66）来自其他国家的输入感染。无症状感染者在深圳的比例不断增加（ = 13.19， < 0.0001）。本地无症状感染总人数超过其他省份（ = 118.83， < 0.0001）。来自其他国家的输入病例中无症状感染者的比例高于国内病例（ = 22.51， < 0.0001，比值比 = 4.90，95% CI：2.40-9.98）。
无症状感染的比例正在增加。因此，开发和应用具有高灵敏度和特异性的诊断方法对于减少 COVID-19 的全球流行至关重要。
