Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
School of Health Humanities, Peking University, Beijing, China.
JAMA Netw Open. 2021 Dec 1;4(12):e2137257. doi: 10.1001/jamanetworkopen.2021.37257.
Asymptomatic infections are potential sources of transmission for COVID-19.
To evaluate the percentage of asymptomatic infections among individuals undergoing testing (tested population) and those with confirmed COVID-19 (confirmed population).
PubMed, EMBASE, and ScienceDirect were searched on February 4, 2021.
Cross-sectional studies, cohort studies, case series studies, and case series on transmission reporting the number of asymptomatic infections among the tested and confirmed COVID-19 populations that were published in Chinese or English were included.
This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Random-effects models were used to estimate the pooled percentage and its 95% CI. Three researchers performed the data extraction independently.
The percentage of asymptomatic infections among the tested and confirmed populations.
Ninety-five unique eligible studies were included, covering 29 776 306 individuals undergoing testing. The pooled percentage of asymptomatic infections among the tested population was 0.25% (95% CI, 0.23%-0.27%), which was higher in nursing home residents or staff (4.52% [95% CI, 4.15%-4.89%]), air or cruise travelers (2.02% [95% CI, 1.66%-2.38%]), and pregnant women (2.34% [95% CI, 1.89%-2.78%]). The pooled percentage of asymptomatic infections among the confirmed population was 40.50% (95% CI, 33.50%-47.50%), which was higher in pregnant women (54.11% [95% CI, 39.16%-69.05%]), air or cruise travelers (52.91% [95% CI, 36.08%-69.73%]), and nursing home residents or staff (47.53% [95% CI, 36.36%-58.70%]).
In this meta-analysis of the percentage of asymptomatic SARS-CoV-2 infections among populations tested for and with confirmed COVID-19, the pooled percentage of asymptomatic infections was 0.25% among the tested population and 40.50% among the confirmed population. The high percentage of asymptomatic infections highlights the potential transmission risk of asymptomatic infections in communities.
无症状感染是 COVID-19 的潜在传播源。
评估接受检测的个体（检测人群）和确诊 COVID-19 个体（确诊人群）中的无症状感染比例。
2021 年 2 月 4 日在 PubMed、EMBASE 和 ScienceDirect 上进行了检索。
纳入了以中文或英文发表的报告检测人群和确诊 COVID-19 人群中无症状感染数量的横断面研究、队列研究、病例系列研究和传播病例系列研究。
本荟萃分析遵循系统评价和荟萃分析的 Preferred Reporting Items（PRISMA）指南进行。使用随机效应模型估计汇总百分比及其 95%置信区间。三名研究人员独立进行了数据提取。
检测人群和确诊人群中的无症状感染比例。
纳入了 95 项独特的合格研究，涵盖了 29776306 名接受检测的个体。检测人群中无症状感染的汇总百分比为 0.25%（95%CI，0.23%-0.27%），在疗养院居民或工作人员（4.52%[95%CI，4.15%-4.89%]）、航空或邮轮旅行者（2.02%[95%CI，1.66%-2.38%]）和孕妇（2.34%[95%CI，1.89%-2.78%]）中更高。确诊人群中无症状感染的汇总百分比为 40.50%（95%CI，33.50%-47.50%），在孕妇（54.11%[95%CI，39.16%-69.05%]）、航空或邮轮旅行者（52.91%[95%CI，36.08%-69.73%]）和疗养院居民或工作人员（47.53%[95%CI，36.36%-58.70%]）中更高。
在本荟萃分析中，对接受检测和确诊 COVID-19 的人群进行了 SARS-CoV-2 无症状感染比例的研究，检测人群中无症状感染的汇总百分比为 0.25%，确诊人群中无症状感染的汇总百分比为 40.50%。无症状感染的高比例突出了社区中无症状感染的潜在传播风险。
Zotero 插件