CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), 70124 Bari, Italy.
Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario "Ernesto Quagliariello", University of Bari \'Aldo Moro\', 70125 Bari, Italy.
Curr Med Chem. 2022;29(6):1061-1082. doi: 10.2174/0929867328666210810154732.
Cancer is a pathology that impacts in a profound manner all over the world. The election strategy against cancer often uses chemotherapy and radiotherapy, which, more often than not, can present many side effects and are not always considered reliable efficacy. By contrast, it is widely known that a diet rich in fruit and vegetables has a protective effect against cancer insurgence and development. Polyphenols are generally believed to be responsible for those beneficial actions, at least partially. In this review, we highlight the metabolic interaction between polyphenols and our metabolism and discuss their potential for anticancer prevention and therapy.
癌症是一种在全球范围内深刻影响的病理学。癌症防治策略通常采用化疗和放疗,但这些方法往往会带来许多副作用,且并非总是被认为具有可靠的疗效。相比之下,人们普遍认为富含水果和蔬菜的饮食对预防和控制癌症的发生和发展具有保护作用。多酚通常被认为至少部分地对这些有益作用负责。在这篇综述中,我们强调了多酚与我们代谢之间的代谢相互作用,并讨论了它们在癌症预防和治疗方面的潜力。