Department of Psychology, Florida State University, Tallahassee, USA.
Department of Psychology, Florida State University, Tallahassee, USA.
J Affect Disord. 2021 Nov 1;294:776-785. doi: 10.1016/j.jad.2021.07.091. Epub 2021 Jul 30.
Previous research has found deficits in both the reward positivity (RewP) and P300 components of the event-related potential (ERP) in relation to depression. The current study examined whether the P300, elicited from imperative stimuli in a gambling task, relates to depression - and can be utilized in tandem with the RewP to better account for individual differences in depression.
In the current study, 80 adults with current depression (M = 39.65, 79% female) and 43 healthy controls (M = 37.02, 81% female) completed clinical interviews, self-report questionnaires, and the doors gambling task while EEG was recorded.
Results indicated a reduced P300 to doors stimuli (i.e., doors P300) in depression, especially among depressed individuals reporting heightened anhedonia. Gain and loss feedback P300s did not differ between groups. Moreover, the doors P300 moderated the association between RewP and depression status: individuals with relatively intact reward processing (i.e., larger RewP) were more likely to be currently depressed if they exhibited a reduced P300.
The majority of the sample identified as Caucasian which reduces generalizability of current results. Additionally, the current study is cross sectional design which limits insight into how these ERPs coincide with changes in the disorder.
The current study demonstrates that a novel P300 component to the doors stimulus appears to be blunted in currently depressed individuals, and that using the doors P300 in combination with the RewP accounts for significantly more variance in depression.
先前的研究发现，与抑郁症相关的事件相关电位（ERP）中的奖励正波（RewP）和 P300 成分都存在缺陷。本研究探讨了在赌博任务中由强制性刺激引起的 P300 是否与抑郁症有关，以及是否可以与 RewP 一起使用，以更好地解释抑郁症个体差异。
在目前的研究中，80 名患有当前抑郁症的成年人（M=39.65，79%为女性）和 43 名健康对照者（M=37.02，81%为女性）完成了临床访谈、自我报告问卷和门赌博任务，同时记录了 EEG。
结果表明，抑郁症患者的门刺激 P300（即门 P300）减少，尤其是在报告快感缺失程度较高的抑郁症患者中。增益和损失反馈的 P300 在两组之间没有差异。此外，门 P300 调节了 RewP 与抑郁状态之间的关系：如果奖励处理相对完整（即 RewP 较大）的个体表现出 P300 减少，则更有可能当前处于抑郁状态。
大多数样本被认定为白种人，这降低了当前结果的普遍性。此外，当前的研究是横断面设计，限制了对这些 ERP 如何与疾病变化同时发生的洞察力。
本研究表明，当前抑郁个体的门刺激新 P300 成分似乎减弱，并且使用门 P300 与 RewP 相结合可以更好地解释抑郁症的更多变异性。
