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血液和骨髓移植临床研究网络试验 1102 开启高危骨髓增生异常综合征造血细胞移植的新纪元:实施中的挑战与机遇。

Blood and Marrow Transplant Clinical Trials Network Study 1102 heralds a new era in hematopoietic cell transplantation in high-risk myelodysplastic syndromes: Challenges and opportunities in implementation.

机构信息

Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.

Rush University Medical Center, Chicago, Illinois.

出版信息

Cancer. 2021 Dec 1;127(23):4339-4347. doi: 10.1002/cncr.33826. Epub 2021 Aug 10.

DOI:10.1002/cncr.33826
PMID:34375439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8578257/
Abstract

People who have advanced myelodysplastic syndromes (MDS) may live longer if they get a bone marrow transplant (BMT) instead of other therapies. However, only 15% of people with MDS actually get BMT. Experts say community physicians and transplant physicians should team up with insurance companies and patient advocacy groups to 1) spread this news about lifesaving advances in BMT, 2) ensure that everyone can afford health care, 3) provide emotional support for patients and families, 4) help patients and families get transportation and housing if they need to travel for transplant, and 5) improve care for people of under-represented racial and ethnic backgrounds.

摘要

对于患有骨髓增生异常综合征(MDS)的人来说,如果他们进行骨髓移植(BMT)而不是其他治疗,可能会活得更久。然而,实际上只有 15%的 MDS 患者接受了 BMT。专家表示,社区医生和移植医生应该与保险公司和患者权益组织合作,1)传播关于 BMT 中挽救生命的进展的消息,2)确保每个人都能负担得起医疗保健,3)为患者和家属提供情感支持,4)帮助患者和家属在需要进行移植时获得交通和住房,以及 5)改善代表性不足的种族和族裔背景的人的护理。

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Blood and Marrow Transplant Clinical Trials Network Study 1102 heralds a new era in hematopoietic cell transplantation in high-risk myelodysplastic syndromes: Challenges and opportunities in implementation.血液和骨髓移植临床研究网络试验 1102 开启高危骨髓增生异常综合征造血细胞移植的新纪元:实施中的挑战与机遇。
Cancer. 2021 Dec 1;127(23):4339-4347. doi: 10.1002/cncr.33826. Epub 2021 Aug 10.
2
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[Progress of research on allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimen for treatment of myelodysplastic syndrome - review].[减低强度预处理异基因造血干细胞移植治疗骨髓增生异常综合征的研究进展 - 综述]
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Which Patients Should Undergo Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes, and When Should We Do It?哪些骨髓增生异常综合征患者应接受异基因干细胞移植,以及我们应该何时进行移植?
Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S43-9. doi: 10.1016/j.clml.2015.04.002.
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Allogeneic Hematopoietic Cell Transplantation Is Safe and Effective Treatment in Patients with Myelodysplastic Syndromes Seventy Years and Older.异基因造血细胞移植对70岁及以上骨髓增生异常综合征患者是一种安全有效的治疗方法。
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The Art of Transplantation: Conditioning Intensity for Allogeneic Hematopoietic Stem Cell Transplantation.移植艺术:异基因造血干细胞移植的预处理强度。
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Non-myeloablative conditioning for lower-risk myelodysplastic syndrome with bone marrow blasts less than 5 %-a feasibility study.骨髓原始细胞小于5%的低危骨髓增生异常综合征的非清髓性预处理——一项可行性研究
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Blood. 2017 Mar 30;129(13):1753-1762. doi: 10.1182/blood-2016-06-724500. Epub 2017 Jan 17.
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Transplantation and Cellular Therapy for Older Adults-The MSK Approach.老年人的移植和细胞治疗——MSK 方法。
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本文引用的文献

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Under-use of Hypomethylating Agents in Patients With Higher-risk Myelodysplastic Syndrome in the United States: A Large Population-based Analysis.美国高危骨髓增生异常综合征患者中低甲基化药物的未充分使用:一项大型基于人群的分析。
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Barriers to Hematopoietic Cell Transplantation for Adults in the United States: A Systematic Review with a Focus on Age.美国成人造血细胞移植的障碍:一项以年龄为重点的系统评价
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Evaluating complete remission with partial hematologic recovery (CRh) as a response criterion in myelodysplastic syndromes (MDS).评估骨髓增生异常综合征(MDS)中部分血液学恢复(CRh)作为完全缓解(CR)的反应标准。
Blood Cancer J. 2022 Nov 15;12(11):153. doi: 10.1038/s41408-022-00748-9.
Clinical Decision Making: Communicating Risk and Engaging Patients in Shared Decision Making.
临床决策:沟通风险并让患者参与共同决策。
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4
Myeloablative versus Reduced-Intensity Hematopoietic Cell Transplantation in Myelodysplastic Syndromes: Systematic Review and Meta-analysis.骨髓增生异常综合征中清髓性与减低强度造血细胞移植:系统评价与荟萃分析
Biol Blood Marrow Transplant. 2020 Jun;26(6):e138-e141. doi: 10.1016/j.bbmt.2020.03.003. Epub 2020 Mar 12.
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Impact of Conditioning Intensity of Allogeneic Transplantation for Acute Myeloid Leukemia With Genomic Evidence of Residual Disease.有残留疾病基因组证据的急性髓细胞性白血病异体移植的条件强度的影响。
J Clin Oncol. 2020 Apr 20;38(12):1273-1283. doi: 10.1200/JCO.19.03011. Epub 2019 Dec 20.
6
Comparison of Patient Age Groups in Transplantation for Myelodysplastic Syndrome: The Medicare Coverage With Evidence Development Study.骨髓增生异常综合征患者年龄组在移植中的比较:医疗保险覆盖范围与证据发展研究。
JAMA Oncol. 2020 Apr 1;6(4):486-493. doi: 10.1001/jamaoncol.2019.5140.
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Enrollment of Racial Minorities in Clinical Trials: Old Problem Assumes New Urgency in the Age of Immunotherapy.临床试验中少数族裔的招募:在免疫治疗时代,老问题有了新的紧迫性。
Am Soc Clin Oncol Educ Book. 2019 Jan;39:3-10. doi: 10.1200/EDBK_100021. Epub 2019 May 17.
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Treatment of MDS.骨髓增生异常综合征的治疗。
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Employment, Insurance, and Financial Experiences of Patients with Chronic Graft-versus-Host Disease in North America.北美慢性移植物抗宿主病患者的就业、保险和财务经历。
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