Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Infectious Diseases, Copenhagen University Hospital, Amager Hvidovre Hospital, Hvidovre, Denmark.
Infect Dis (Lond). 2021 Nov-Dec;53(12):953-958. doi: 10.1080/23744235.2021.1957144. Epub 2021 Aug 10.
Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).
A Danish nationwide retrospective clinician-reported survey.
Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22-72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.
The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染在普通变异性免疫缺陷病（CVID）患者中的表现和结局尚未得到充分记录。
一项丹麦全国范围的回顾性临床医生报告调查。
确定了 11 例 CVID 合并 SARS-CoV-2 感染的患者。中位年龄为 50 岁（范围 22-72）。所有患者均接受免疫球蛋白替代治疗。8 例患者存在其他预先存在的合并症。3 例患者在 SARS-CoV-2 感染期间无症状，而 7 例患者发生轻度 2019 年冠状病毒病（COVID-19）。1 例患者病情更严重，出现缺氧，需要吸氧治疗。该患者存在多种合并症，包括众所周知的 COVID-19 重症危险因素。所有患者均康复。
结果表明，CVID 可能不是 COVID-19 重症的危险因素。然而，需要进一步监测这一免疫缺陷人群以证实我们的观察。
