Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Department of Psychiatry, Faculty of Medicine Chiangmai, Chiangmai University, Thailand.
Complement Ther Med. 2021 Sep;61:102765. doi: 10.1016/j.ctim.2021.102765. Epub 2021 Aug 8.
The purpose of this study was to determine the effectiveness of music therapy (MT) with imbedded 10 Hz binaural beats in combination with standard treatment in comparison to standard treatment alone in patients diagnosed with major depressive disorder (MDD).
This study was a randomized controlled trial enrolling 18 MDD adult patients aged ≥20 years old with mild to moderate levels of acute phase depression. The intervention group received MT along with standard treatment, while the control group received only standard treatment. 10-Hz binaural beats were embedded into soothing music. The participants listened to the MT via stereo headphones for 20 min at the clinic and were instructed to continue listening to the track at home at least 3 times/week. The primary outcome was depression score using patient health questionnaire depression screening (PHQ-9). The secondary outcomes were quality of life, measured by the Euro Quality of Life Five-Dimension (EQ-5D) rating, and medications adherence, measured by the medication adherence rating scale (MARS). The outcomes were measured at week 0, week 4, and week 8.
At baseline, the primary outcome of PHQ-9 did not differ between the MT group and the control group (13.3 ± 4.4; 13.9 ± 3.37; p-value = 0.77). After a follow-up of 4 and 8 weeks, the PHQ-9 in the MT group was lower than the control group by 1.50 (95 % confidence interval: -4.46 to 1.46). However, this difference was not significant, with p-value = 0.32. As for the secondary outcome, there were no significant differences in terms of EQ-5D and MARS.
This study concluded that MDD patients who received 10-Hz binaural beat imbedded MT combined with standard treatment had experienced no significant differences compared with control group in terms of depression score, quality of life, and medication adherence. Further studies are suggested to investigate the long-term effect of MT with binaural beats.
本研究旨在比较单纯标准治疗与在标准治疗基础上联合音乐疗法（MT）及嵌入式 10Hz 双耳节拍对诊断为重度抑郁症（MDD）患者的疗效。
这是一项随机对照试验，纳入了 18 例年龄≥20 岁、轻度至中度急性抑郁的 MDD 成年患者。干预组接受 MT 联合标准治疗，对照组仅接受标准治疗。在舒缓的音乐中嵌入 10Hz 双耳节拍。参与者在诊所通过立体声耳机听 20 分钟的 MT，并被指示在家中至少每周听 3 次。主要结局指标是患者健康问卷抑郁筛查（PHQ-9）的抑郁评分。次要结局指标是生活质量，用欧洲生活质量五维（EQ-5D）评定量表测量；药物依从性，用药物依从性评定量表（MARS）测量。在基线、4 周和 8 周时评估结局。
在基线时，MT 组和对照组的 PHQ-9 主要结局无差异（13.3±4.4；13.9±3.37；p 值=0.77）。在 4 周和 8 周随访时，MT 组的 PHQ-9 比对照组低 1.50（95%置信区间：-4.46 至 1.46），但差异无统计学意义（p 值=0.32）。次要结局方面，EQ-5D 和 MARS 均无显著差异。
本研究得出结论，在抑郁评分、生活质量和药物依从性方面，接受嵌入式 10Hz 双耳节拍 MT 联合标准治疗的 MDD 患者与对照组相比无显著差异。建议进一步研究以探讨 MT 与双耳节拍的长期疗效。
