Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China; Department of Respiratory and Critical Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Complement Ther Clin Pract. 2021 Nov;45:101470. doi: 10.1016/j.ctcp.2021.101470. Epub 2021 Aug 4.
To evaluate the efficacy and safety of Chinese herbal medicine (CHM) on symptoms of depression and anxiety complicated by chronic obstructive pulmonary disease (COPD).
Literature from 8 electronic medical databases were searched for meta-analysis using RevMan (version 5.3) and Stata (version 12.0) software. The GRADE Pro Guideline Development Tool and TSA Viewer (version.0.9.5.10 beta) were adopted to evaluate the certainty and conclusiveness of the evidence.
26 studies involving 2529 participants were identified. CHM demonstrated significant lower scores on the Hamilton Depression Rating Scale, Self-Rating Depression Scale, Hamilton Anxiety Rating Scale, and Self-Rating Anxiety Scale compared to the control group without CHM. Moreover, CHM showed favorable safety.
The evidence verified the efficacy and safety of CHM on relieving depression and anxiety in COPD. However, further large-scale and rigorously designed studies are urgently warranted to strengthen the evidence.
评价中药（CHM）治疗合并慢性阻塞性肺疾病（COPD）的抑郁和焦虑症状的疗效和安全性。
使用 RevMan（版本 5.3）和 Stata（版本 12.0）软件对 8 个电子医学数据库中的文献进行荟萃分析。采用 GRADE Pro 指南开发工具和 TSA Viewer（版本.0.9.5.10 beta）评估证据的确定性和结论性。
共纳入 26 项研究，涉及 2529 名参与者。与未使用 CHM 的对照组相比，CHM 可显著降低汉密尔顿抑郁量表、自评抑郁量表、汉密尔顿焦虑量表和自评焦虑量表的评分。此外，CHM 表现出良好的安全性。
证据证实了 CHM 缓解 COPD 患者抑郁和焦虑的疗效和安全性。然而，迫切需要进一步开展大规模和设计严谨的研究来加强证据。
