Yokotani K, Okuma Y, Osumi Y
Department of Pharmacology, Kochi Medical School, Japan.
Jpn J Pharmacol. 1987 Oct;45(2):288-91. doi: 10.1254/jjp.45.288.
The effect of intracerebroventricularly (i.c.v.) administered nicotine was investigated in urethane-anesthetized rats. I.c.v., but not intravenously, administered nicotine (300 and 600 nmole/animal) inhibited the increase in gastric acid output induced by electrical stimulation of the vagus nerve. This antisecretory effect of nicotine was abolished by combined pretreatment with adrenalectomy and 6-hydroxydopamine (50 mg/kg, i.v., 3 days before). I.c.v.-administered nicotine also raised the blood levels of catecholamines. These observations suggest that i.c.v. administered nicotine leads to excitation of the central sympatho-adrenomedullary outflow and inhibits gastric acid output induced by stimulation of the vagus nerve.
在乌拉坦麻醉的大鼠中研究了脑室内（i.c.v.）注射尼古丁的作用。脑室内而非静脉内注射尼古丁（300和600纳摩尔/动物）可抑制电刺激迷走神经引起的胃酸分泌增加。尼古丁的这种抗分泌作用在肾上腺切除和6-羟基多巴胺联合预处理（50毫克/千克，静脉内注射，提前3天）后被消除。脑室内注射尼古丁还会提高儿茶酚胺的血液水平。这些观察结果表明，脑室内注射尼古丁会导致中枢交感-肾上腺髓质传出神经兴奋，并抑制迷走神经刺激引起的胃酸分泌。
