脑室注射前列腺素E2对麻醉大鼠胃酸分泌的抑制作用
Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin e2 in anaesthetized rats.
作者信息
Puurunen J
出版信息
Br J Pharmacol. 1983 Jan;78(1):131-5. doi: 10.1111/j.1476-5381.1983.tb09372.x.
Abstract
1 The effect of intracerebroventricularly (i.c.v) administered prostaglandin E2 (PGE2) on gastric acid secretion was studied in anaesthetized rats. 2 Intracerebroventricular injections of 1 and 3 micrograms of PGE2 inhibited gastric acid secretion induced by insulin, electrical vagal stimulation and acetylcholine in a dose-dependent manner. 3 Intravenous injections of 1,3 and 10 micrograms of PGE2 had no effect on insulin-stimulated gastric acid output. 4 The results indicate that upon i.c.v. administration PGE2 inhibits gastric acid secretion by acting centrally and not peripherally after leakage from the central nervous system.
摘要
- 研究了在麻醉大鼠中脑室内注射前列腺素E2（PGE2）对胃酸分泌的影响。2. 脑室内注射1微克和3微克PGE2以剂量依赖的方式抑制胰岛素、电迷走神经刺激和乙酰胆碱诱导的胃酸分泌。3. 静脉注射1微克、3微克和10微克PGE2对胰岛素刺激的胃酸分泌无影响。4. 结果表明，脑室内给药时，PGE2通过中枢作用而非从中枢神经系统漏出后的外周作用来抑制胃酸分泌。
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