Yokotani K, Okuma Y, Osumi Y
Department of Pharmacology, Kochi Medical School, Japan.
Eur J Pharmacol. 1995 Jun 12;279(2-3):233-9. doi: 10.1016/0014-2999(95)00166-i.
The inhibitory mechanism of gastric acid secretion induced by human recombinant interleukin-1 beta was investigated in bilaterally vagotomized, urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta (10, 50 and 100 ng/animal) dose dependently inhibited the gastric acid secretion induced by electrical stimulation of the vagus nerve at 3 Hz. Inhibition of gastric acid secretion induced by interleukin-1 beta (50 ng/animal) was abolished both by splanchnectomy and by phentolamine (5 mg/kg i.m.). Greater splanchnic nerves ramify into the adrenal branch and gastric sympathetic preganglionic branch. The interleukin-1 beta (50 ng/animal)-induced inhibition was also abolished by intracerebroventricular pretreatment with indomethacin (500 micrograms/animal), while pretreatment with the same dose of this reagent by the intraperitoneal route was without effect. These results suggest that centrally administered interleukin-1 beta induces a prostaglandin-mediated central excitation of the sympatho-adrenomedullary system, and the resultant activation of gastric alpha-adrenoceptors inhibits the vagally stimulated gastric acid secretion in rats.
在双侧迷走神经切断、氨基甲酸乙酯麻醉的大鼠中，研究了人重组白细胞介素-1β诱导胃酸分泌的抑制机制。脑室内注射白细胞介素-1β（10、50和100 ng/只动物）剂量依赖性地抑制了3 Hz电刺激迷走神经诱导的胃酸分泌。白细胞介素-1β（50 ng/只动物）诱导的胃酸分泌抑制在去内脏神经和酚妥拉明（5 mg/kg，腹腔注射）处理后均被消除。内脏大神经分支为肾上腺分支和胃交感神经节前分支。脑室内预先注射吲哚美辛（500 μg/只动物）也可消除白细胞介素-1β（50 ng/只动物）诱导的抑制作用，而经腹腔途径预先注射相同剂量的该试剂则无效。这些结果表明，中枢给予白细胞介素-1β可诱导前列腺素介导的交感-肾上腺髓质系统的中枢兴奋，由此激活胃α-肾上腺素能受体抑制大鼠迷走神经刺激的胃酸分泌。
