Wixson S K, White W J, Hughes H C, Marshall W K, Lang C M
Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Lab Anim Sci. 1987 Dec;37(6):731-5.
The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike previous studies in rodents, this study has quantitated noxious stimulus perception following a temporal sequence of observations. Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital. Results of this study also suggested that a spatial orientation, similar to that present in man, exists within the CNS of rats for receipt of noxious stimulation.
用于实验室研究的大鼠使用量增加，这使得更深入了解它们对疼痛或有害刺激的感知以及减轻此类刺激的方法变得更加紧迫。本研究评估了四种不同的注射用药物，戊巴比妥、芬太尼-氟哌利多（英诺华-兽医版）、氯胺酮-赛拉嗪和氯胺酮-地西泮。与以往对啮齿动物的研究不同，本研究按照时间顺序观察，对有害刺激感知进行了量化。结果显示，英诺华-兽医版对有害刺激感知的抑制作用最大，氯胺酮-赛拉嗪和氯胺酮-地西泮的抑制作用较小，戊巴比妥对伤害感受的减轻作用最小。本研究结果还表明，大鼠中枢神经系统内存在一种类似于人类的空间定向，用于接收有害刺激。
