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伊拉克新冠疫情药物治疗评估

Evaluation of the Pharmacologic Treatment of COVID-19 Pandemic in Iraq.

作者信息

Darweesh Omeed, Abdulrazzaq Ghayth M, Al-Zidan Radhwan N, Bebane Pshtiwan, Merkhan Marwan, Aldabbagh Ruya, AlOmari Nohad

机构信息

College of Pharmacy, Al-kitab University, Kirkuk, Iraq.

College of Pharmacy, University of Mosul, Mosul, Iraq.

出版信息

Curr Pharmacol Rep. 2021;7(4):171-178. doi: 10.1007/s40495-021-00262-9. Epub 2021 Aug 5.

Abstract

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or COVID-19) has been detrimental to human health, economy, and wellbeing. Little information is known on the epidemiology and outcome of the disease in a localized community within Iraq. We carried out an audit of confirmed cases of COVID-19 in the Kirkuk General Hospital. Data from the 20th of June to the 31st of July, 2020, were collected and analyzed. Suspected COVID-19 cases were confirmed by real-time polymerase chain reaction (RT-PCR). Data on clinical symptoms, age, and treatment protocols were analyzed concerning the outcome. Our study included a total of 200 individual confirmed COVID-19 patients. The majority of cases 55% ( = 110) displayed severe symptoms, while 32.5% (65 cases) and 12.5% (25 cases) of patients displayed moderate to mild symptoms, respectively. The rate of death in the referred patients was 5%. Most patients admitted to the hospital for treatment recovered and were discharged from the hospital within 5 to 30 days post-diagnosis. Statistical analysis revealed that patients treated with oseltamivir, hydroxychloroquine, and azithromycin in combination with vitamins C and D have shorter hospital stay compared to patients receiving the same therapeutic protocol in combination with steroids. Moreover, a higher mortality rate (4.5%) was observed in patients treated with oseltamivir, hydroxychloroquine, ceftriaxone, and steroids. This study highlights a significant relationship between age, secondary ailments, and the choice of medications as simple predictors of the outcome of COVID-19.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2,即新型冠状病毒肺炎)对人类健康、经济和福祉造成了不利影响。关于伊拉克一个局部社区内该疾病的流行病学和转归情况,人们所知甚少。我们对基尔库克总医院确诊的新型冠状病毒肺炎病例进行了一次审核。收集并分析了2020年6月20日至7月31日的数据。疑似新型冠状病毒肺炎病例通过实时聚合酶链反应(RT-PCR)确诊。分析了有关临床症状、年龄和治疗方案的转归数据。我们的研究共纳入了200例确诊的新型冠状病毒肺炎患者。大多数病例(55%,即110例)表现出严重症状,而分别有32.5%(65例)和12.5%(25例)的患者表现出中度至轻度症状。转诊患者的死亡率为5%。大多数入院治疗的患者康复,并在确诊后5至30天内出院。统计分析显示,与接受相同治疗方案联合使用类固醇的患者相比,联合使用奥司他韦、羟氯喹和阿奇霉素以及维生素C和D进行治疗的患者住院时间更短。此外,在接受奥司他韦、羟氯喹、头孢曲松和类固醇治疗的患者中观察到更高的死亡率(4.5%)。本研究强调了年龄、继发性疾病和药物选择之间的显著关系,这些可作为新型冠状病毒肺炎转归的简单预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02fc/8339216/f3b7834523ee/40495_2021_262_Fig1_HTML.jpg

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