Zakład Biochemii, Katedra Chemii i Biochemii Medycznej, Uniwersytet Medyczny w Łodzi.
Zakład Farmakologii i Toksykologii, Międzywydziałowa Katedra Farmakologii Ogólnej i Klinicznej, Uniwersytet Medyczny w Łodzi.
Postepy Biochem. 2021 Feb 12;67(1):34-43. doi: 10.18388/pb.2021_367. Print 2021 Mar 31.
Constipation occurs more often in old patients, because the intestinal peristalsis decreases with aging. Constipation is caused due to impaired motility of the intestines, intestinal barrier damage and the imbalance between the absorption and secretion of water and electrolytes, as well as disturbed production and release of intestinal hormones, infiltration of the gastrointestinal tract with immune cells, excessive production of pro-inflammatory cytokines and the alterations in the functions of enteric nervous system. In this review we will discuss the most important issues associated with the process of aging of the digestive tract, focusing on the enteric nervous system.
老年人中便秘更为常见，因为肠道蠕动随年龄增长而减少。便秘是由肠道运动障碍、肠道屏障损伤以及水和电解质吸收与分泌失衡、肠道激素产生和释放紊乱、胃肠道免疫细胞浸润、促炎细胞因子过度产生以及肠神经系统功能改变引起的。在这篇综述中，我们将讨论与消化道老化过程相关的最重要问题，重点关注肠神经系统。
