可见光介导的活性叔醇的脱氧炔基化反应
Visible-Light-Mediated Deoxyalkynylation of Activated Tertiary Alcohols.
作者信息
Li Muzi, Liu Tao, Li Jiajun, He Hengchi, Dai Haotian, Xie Jin
机构信息
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
出版信息
J Org Chem. 2021 Sep 3;86(17):12386-12393. doi: 10.1021/acs.joc.1c01356. Epub 2021 Aug 11.
In this paper, visible-light-induced deoxyalkynylation of activated tertiary alcohols has been successfully performed under mild reaction conditions with ethynylbenziodoxole as the readily available alkynylation reagent. The desired C(sp)-C(sp) coupling can smoothly occur with 4-CzIPN as a photocatalyst, affording a wide range of valuable alkynylation products bearing quaternary carbon centers in 37-84% yields.
在本文中，以乙炔基苯碘酰亚胺作为易于获得的炔基化试剂，在温和的反应条件下成功实现了可见光诱导的活性叔醇的脱氧炔基化反应。以4-CzIPN作为光催化剂时，所需的C(sp)-C(sp)偶联反应能够顺利发生，以37-84%的产率得到了一系列带有季碳中心的有价值的炔基化产物。
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