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在发育中的背根神经节中，前蛋白及其受体 GRP37 和 GPR37L1 的表达增加。

The expression of prosaposin and its receptors, GRP37 and GPR37L1, are increased in the developing dorsal root ganglion.

机构信息

Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

Department of Otorhinolaryngology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

出版信息

PLoS One. 2021 Aug 11;16(8):e0255958. doi: 10.1371/journal.pone.0255958. eCollection 2021.

DOI:10.1371/journal.pone.0255958
PMID:34379697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8357083/
Abstract

Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A-D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR37 and GPR37L1 were recognized as PSAP receptors, but their functions have not yet been clarified. In this study, we examined the distribution of PSAP and its receptors in the dorsal root ganglion (DRG) during development using specific antibodies, and showed that PSAP accumulates primarily in lysosomes and is dispersed throughout the cytoplasm of satellite cells. Later, PSAP colocalized with two receptors in satellite cells, and formed a characteristic ring shape approximately 8 weeks after birth, during a period of rapid DRG development. This ring shape, which was only observed around larger neurons, is evidence that several satellite cells are synchronously activated. We found that sortilin, a transporter of a wide variety of intracellular proteins containing PSAP, is strongly localized to the inner side of satellite cells, which contact the neuronal surface. These findings suggest that PSAP and GPR37/GPR37L1 play a role in activating both satellite and nerve cells.

摘要

原前体蛋白 (PSAP) 是一种高度保守的糖蛋白，是 saposin A-D 的前体。越来越多的证据表明 PSAP 是一种神经营养因子，也是溶酶体酶的调节剂。最近，孤儿 G 蛋白偶联受体 GPR37 和 GPR37L1 被认为是 PSAP 的受体，但它们的功能尚未阐明。在这项研究中，我们使用特异性抗体研究了 PSAP 及其受体在发育过程中背根神经节 (DRG) 中的分布，并表明 PSAP 主要积聚在溶酶体中，并分散在卫星细胞的细胞质中。后来，PSAP 与卫星细胞中的两种受体共定位，并在出生后约 8 周形成一个特征性的环，此时 DRG 快速发育。这种仅在较大神经元周围观察到的环形状表明几个卫星细胞同步被激活。我们发现，载有 PSAP 的各种细胞内蛋白的转运蛋白 sortilin 强烈定位于与神经元表面接触的卫星细胞的内侧。这些发现表明 PSAP 和 GPR37/GPR37L1 可能在激活卫星细胞和神经细胞方面发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4921/8357083/939f8fac42ad/pone.0255958.g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4921/8357083/f1be6a6adffb/pone.0255958.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4921/8357083/939f8fac42ad/pone.0255958.g011.jpg

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