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发育性髋关节发育不良的流行病学:日本国家数据库分析。

Epidemiology of Developmental Dysplasia of the Hip: Analysis of Japanese National Database.

机构信息

Department of Hygiene, Public Health, and Preventative Medicine, Showa University School of Medicine.

Department of Orthopaedic Surgery, National Rehabilitation Center for Children with Disabilities.

出版信息

J Epidemiol. 2023 Apr 5;33(4):186-192. doi: 10.2188/jea.JE20210074. Epub 2022 Apr 15.

Abstract

BACKGROUND

Developmental dysplasia of the hip (DDH) is a cluster of hip development disorders that affects infants. The incidence of DDH-related dislocation (DDH-dislocation) is reportedly 0.1-0.3%; however, the nationwide incidence of DDH-dislocation in Japan has not been previously reported. The primary aim of this study was to report the nationwide incidence of DDH-dislocation in Japan using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), and to examine its regional variation across Japan.

METHODS

This was a retrospective birth cohort study using the NDB. Data on patients born between 2011 and 2013 and assigned DDH-dislocation-related disease codes during 2011-2018 were extracted. Among these, patients who underwent treatment for DDH-dislocation between 2011 and 2018 were defined as patients with DDH-dislocation.

RESULTS

Across the 2011, 2012, and 2013 birth cohorts, 2,367 patients were diagnosed with DDH-dislocation, yielding the nationwide incidence of 0.076%. Region-specific incidence rates were almost similar across Japan. Secondary analyses revealed that 273 (11.5%) patients were diagnosed at the age of ≥1 year. The effect of birth during the cold months on the incidence of DDH-dislocation was significant (relative risk [RR] = 1.89, 95% confidence interval [CI]: 1.75-2.06). The risk of DDH-dislocation among girls was approximately seven times higher than that among boys.

CONCLUSION

This is the first study to report the nationwide incidence of DDH-dislocation in Japan, which was estimated at 0.076%. The regional variation was trivial and unlikely to be clinically significant. Thus, the incidence rates were approximately equal across all regions in Japan.

摘要

背景

发育性髋关节发育不良(DDH)是一组影响婴儿的髋关节发育障碍。DDH 相关脱位(DDH-脱位)的发病率据报道为 0.1-0.3%;然而,日本全国范围内的 DDH-脱位发病率尚未有报道。本研究的主要目的是使用日本国民健康保险索赔和特定健康检查数据库(NDB)报告日本全国范围内的 DDH-脱位发病率,并研究其在日本各地的地域差异。

方法

这是一项使用 NDB 的回顾性出生队列研究。提取了 2011 年至 2013 年出生且在 2011-2018 年期间分配了 DDH-脱位相关疾病代码的患者的数据。其中,在 2011-2018 年间接受 DDH-脱位治疗的患者被定义为 DDH-脱位患者。

结果

在 2011 年、2012 年和 2013 年的出生队列中,共有 2367 例患者被诊断为 DDH-脱位,全国发病率为 0.076%。日本各地的区域特定发病率几乎相似。二次分析显示,273 例(11.5%)患者在≥1 岁时被诊断出患有 DDH-脱位。出生在寒冷月份对 DDH-脱位发病率的影响显著(相对风险 [RR] = 1.89,95%置信区间 [CI]:1.75-2.06)。女孩患 DDH-脱位的风险约为男孩的七倍。

结论

这是第一项报告日本全国范围内 DDH-脱位发病率的研究,估计发病率为 0.076%。地域差异微不足道,不太可能具有临床意义。因此,日本各地的发病率大致相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8af/9939923/eedfde531608/je-33-186-g001.jpg

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