DNA 状态的转换过滤了调频系统中的外在噪声。
The switch of DNA states filtering the extrinsic noise in the system of frequency modulation.
机构信息
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Sec. 3, Chung-Hsiao E. Road, Taipei City, 10608, Taiwan.
出版信息
Sci Rep. 2021 Aug 11;11(1):16309. doi: 10.1038/s41598-021-95365-0.
There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.
有一种特殊的节点，上游元件的大噪声并不总是导致下游元件的广泛分布。这个节点是 DNA，上游元件是 TF，下游元件是 mRNA 和蛋白质。通过对受大肠杆菌 fim 操纵子启发的基因电路应用随机模拟算法（SSA），我们发现细胞将上游转录因子（TF）的分布转换为 DNA 的跃迁频率。然后，细胞进行逆变换，将 DNA 的跃迁频率转换为下游产物的分布。由于这个特殊的特性，在频率调制系统中的 DNA 能够重置噪声。通过概率生成函数，我们知道了赋予这种有趣现象的参数值范围。
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