Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangdong Province, 510630, Guangzhou, China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
BMC Pregnancy Childbirth. 2021 Aug 12;21(1):551. doi: 10.1186/s12884-021-04020-z.
We encourage Hepatitis B virus-infected mothers to breastfeed postpartum, even when continuing pregnancy category B nucleos(t)ide analogs (NAs) treatment. However, a large proportion of the Hepatitis B virus-infected mothers were noncompliant with this breastfeeding recommendation. This study aimed to investigate the factors associated with noncompliance with breastfeeding recommendation in Hepatitis B virus-infected mothers who had received NAs treatment during pregnancy.
A total of 155 mothers with chronic hepatitis B receiving NAs treatment for preventing mother-to-child transmission during the late gestation period were included and divided into exclusive breastfeeding (n = 63), mixed feeding (n = 34), and artificial feeding (n = 58) groups according to the postpartum feeding methods. Independent variables associated with feeding methods were analyzed using logistic regression analysis.
Compared to the breastfeeding and mixed feeding groups, the artificial feeding group had significantly more multiparity, later postpartum timing of stopping NAs treatment, and a lower proportion of having knowledge of NAs medications (all P < 0.05). In addition, multivariable logistic regression analysis confirmed that multiparity, later postpartum timing of stopping NAs treatment, and lacking knowledge of medication were independent factors associated with noncompliance with breastfeeding recommendation.
Hepatitis B virus-infected mothers who stopped NAs treatment at late postpartum period or had less knowledge of medication were more likely to be noncompliant with breastfeeding recommendation. Strengthening health education for participants taking NAs may be an important method to improve compliance with breastfeeding recommendation.
我们鼓励乙型肝炎病毒（HBV）感染的母亲进行产后母乳喂养，即使她们继续接受妊娠 B 类核苷（酸）类似物（NAs）治疗。然而，很大一部分 HBV 感染的母亲不遵守这一母乳喂养建议。本研究旨在探讨在接受妊娠期间 NAs 治疗的 HBV 感染母亲中，与不遵守母乳喂养建议相关的因素。
共纳入 155 例接受 NAs 治疗以预防母婴传播的慢性乙型肝炎母亲，根据产后喂养方式分为纯母乳喂养组（n=63）、混合喂养组（n=34）和人工喂养组（n=58）。采用逻辑回归分析与喂养方式相关的独立变量。
与母乳喂养和混合喂养组相比，人工喂养组多胎妊娠、产后停止 NAs 治疗的时间较晚、对 NAs 药物知识的知晓率较低（均 P<0.05）。此外，多变量逻辑回归分析证实，多胎妊娠、产后停止 NAs 治疗的时间较晚、缺乏药物知识是不遵守母乳喂养建议的独立相关因素。
产后晚期停止 NAs 治疗或对药物知识了解较少的 HBV 感染母亲更有可能不遵守母乳喂养建议。加强接受 NAs 治疗的参与者的健康教育可能是提高母乳喂养建议依从性的重要方法。
