初诊乳腺癌患者的心血管特征。

Cardiovascular characteristics of patients initially diagnosed breast cancer.

机构信息

Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400000, China.

School of Public Health and Management, Research Center for Medicine and Social Development, Collaborative Innovation of Chongqing Medical University, Chongqing, 400000, China.

出版信息

J Cardiothorac Surg. 2021 Aug 12;16(1):231. doi: 10.1186/s13019-021-01608-6.

DOI:10.1186/s13019-021-01608-6

PMID:34384462

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8359046/

Abstract

OBJECTIVE

We aimed to explore the cardiovascular characteristics of patients who were initially diagnosed with breast cancer.

METHODS

A total of 600 patients who were diagnosed with primary breast cancer were included in this retrospective study. The data of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoprotein (a) (LP (a)) and serum uric acid were collected. Univariate analysis was used to evaluate the cardiovascular risk factors (CVRFs) in patients with breast cancer. The arteriosclerotic cardiovascular disease (ASCVD) risk assessment was performed. Multivariate analysis was used to identify the factors that influenced axillary lymph node metastasis (ALNM).

RESULTS

Compared with the premenopausal group, the prevalence of overweight/obesity (47.6% vs. 35.2%), diabetes (12.8% vs. 4.3%) and hypertension (49.7% vs. 26.3%) were significantly increased in the postmenopausal group (p < 0.05). Comparisons of rural patients and urban patients showed that there were significant differences in the diagnostic age (49.94 ± 9.92 vs. 52.59 ± 11.13) in the rural patients was notably younger in comparison with the urban patients (p < 0.05). However, the number of menopausal patients (44.3% vs. 53.3%) in the rural group were decreased in comparison with the urban group (p < 0.05). In ASCVD risk stratification, the proportion of low-risk patients (56.4% vs. 90.8%), medium-risk patients (20.6% vs 0.3%) and high-risk patients (19.3% vs. 6.6%) were significantly different between the postmenopausal group and premenopausal group (p < 0.05). Residence (OR 0.735; 95% CI 0.516-1.046; p = 0.087), the number of children (OR 1.250; 95% CI 0.990-1.578; p = 0.061) and LP (a) of ≥ 500 mg/L (OR 0.603; 95% CI 0.342-1.063; p = 0.080) were independent influencing factors of ALNM.

CONCLUSION

Postmenopausal patients have more CVRFs and higher risks of ASCVD than premenopausal patients initially diagnosed with breast cancer. There was a correlation between CVRFs and ALNM in patients with breast cancer.

摘要

目的

探讨初诊乳腺癌患者的心血管特征。

方法

回顾性分析 600 例初诊乳腺癌患者的临床资料，收集患者空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、脂蛋白（a）[LP（a）]、血尿酸等数据。采用单因素分析评估乳腺癌患者的心血管危险因素（CVRFs），进行动脉粥样硬化性心血管疾病（ASCVD）风险评估。采用多因素分析识别影响腋窝淋巴结转移（ALNM）的因素。

结果

与绝经前组相比，绝经后组超重/肥胖（47.6%比 35.2%）、糖尿病（12.8%比 4.3%）和高血压（49.7%比 26.3%）的患病率显著增加（p<0.05）。农村患者与城市患者比较，农村患者的诊断年龄（49.94±9.92比 52.59±11.13）明显小于城市患者（p<0.05），而农村患者的绝经患者比例（44.3%比 53.3%）明显低于城市患者（p<0.05）。在 ASCVD 风险分层中，绝经后组低危患者比例（56.4%比 90.8%）、中危患者比例（20.6%比 0.3%）和高危患者比例（19.3%比 6.6%）明显低于绝经前组（p<0.05）。居住地（OR 0.735；95%CI 0.516~~1.046；p=0.087）、子女数（OR 1.250；95%CI 0.990~~1.578；p=0.061）和 LP（a）≥500mg/L（OR 0.603；95%CI 0.342~1.063；p=0.080）是 ALNM 的独立影响因素。