Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Cell Host Microbe. 2021 Aug 11;29(8):1216-1217. doi: 10.1016/j.chom.2021.07.010.
Engagement of LC3-associated phagocytosis (LAP) in response to the uptake of certain particles modulates innate immune responses. Now in Cell Host and Microbe, Akoumianaki et al. (2021) show how a regulatory role of IL-6 on LAP may be at the core of susceptibility to secondary infection during severe sepsis.
LC3 相关噬作用(LAP)与某些颗粒的摄取有关,从而调节先天免疫反应。在《细胞宿主与微生物》杂志上,Akoumianaki 等人(2021 年)展示了白细胞介素 6(IL-6)对 LAP 的调节作用可能是严重脓毒症继发感染易感性的核心机制。